Effect of Annona squamosa extract combined with permetrin 5% on scabies lesion
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1
Diponegoro University, Department of Dermatology and Venereology, Indonesia
Background
Scabies is one of the top six dermatology disease in the world as stated by World Health Organization and one of the top three dermatology disease in Indonesia. Its treatment comprises of many agents. Nowadays, back-to-nature concept using traditional medicine is the preferable choice for scabies. This study aimed to investigate the effect of Annona squamosal leaf extract in combination with permetrin 5% ointment on scabies lesion.
Methods
This was a quasi experimental study with pre- and post-test design conducted in one of Islamic Boarding School in Pati regency, Central Java Province, Indonesia. This study was performed on 24 eligible subjects divided into six groups: control group who received permetrin 5% only, and five treatment groups who received permetrin 5% and Annona squamosal leaf extract ointment in five different concentrations (0.1%, 0.5%, 1%, 5%, and 10% for subgroup T1, T2, T3, T4, and T5, respectively). The preparations were applied once a week for three weeks.
Results
There were significant delta scabies lesions difference between control and subgroup T1 (p=0.021), control and subgroup T2 (p=0.021), control and subgroup T3 (p=0.020), control and subgroup T4 (p=0.021), and control and subgroup T5 (p=0.021).
Conclusion
Annona squamosa leaf essential oil based ointment which used in combination with permetrin 5% could increase scabies treatment effectiveness.
Keywords:
Annona squamosa,
Annona squamosa leaf extract ointment,
Scabies,
Traditional medicine (TM),
scabies adjuvan therapy
Conference:
International Conference on Drug Discovery and Translational Medicine 2018 (ICDDTM '18)
“Seizing Opportunities and Addressing Challenges of Precision Medicine”, Putrajaya, Malaysia, 3 Dec - 5 Feb, 2019.
Presentation Type:
Oral Presentation
Topic:
Infectious diseases
Citation:
Yuniati
R,
Subchan
P,
Irnawanti
I and
Faniyah
F
(2019). Effect of Annona squamosa extract combined with permetrin 5% on scabies lesion.
Front. Pharmacol.
Conference Abstract:
International Conference on Drug Discovery and Translational Medicine 2018 (ICDDTM '18)
“Seizing Opportunities and Addressing Challenges of Precision Medicine”.
doi: 10.3389/conf.fphar.2018.63.00105
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Received:
25 Oct 2018;
Published Online:
17 Jan 2019.
*
Correspondence:
MD, PhD. Renni Yuniati, Diponegoro University, Department of Dermatology and Venereology, Semarang, Central Java, 50275, Indonesia, renniyuniati@yahoo.com