Feeding pattern after intraperitoneal capsaicin desensitization in rats
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1
University of Pecs, Department of Pathophysiology and Gerontology, Hungary
In regulation of satiety and hunger, similarly as in the regulation of postprandial hypermetabolism or fasting hypometabolism there may be a role for neural information from the abdominal cavity. Capsaicin-sensitive afferent abdominal vagal fibers may influence both onset and cessation of feeding, i.e. the feeding pattern, besides influencing the total amount of food consumed. In the present experiments strictly the local (abdominal) afferent fibers were desensitized by intraperitoneal (IP) application of small dose capsaicin. For this purpose, 4-months-old male Wistar rats were injected IP with 2+3 mg/kg capsaicin a few days after IP implantation of telemetric sensors of body temperature, heart rate and spontaneous activity. The animals were placed into the biotelemetric system to record these signals along with feeding frequency (FF) and feeding duration (FD) registered by the infrared Feeding monitor. The amount of consumed food was measured manually. One week after the desensitization a 5-days-long fasting followed to check the usually defective hypometabolic adaptation to fasting in desensitized animals (enhanced tendency for hyperthermic periods), then the food was returned and FD, FF and the food consumption were analyzed. During the first hour of re-feeding, the desensitized rats ate significantly more than the controls and the difference was sustained for well over 3 hours. As expected, in desensitized rats the FD was longer in some fractions of the first hour, but FF was also higher. Besides, the elevation of these parameters was more prolonged. Apparently, IP neural signals influence feeding behavior.
Support: OTKA 49321
Conference:
12th Meeting of the Hungarian Neuroscience Society, Budapest, Hungary, 22 Jan - 24 Jan, 2009.
Presentation Type:
Poster Presentation
Topic:
Homeostatic regulatory mechanisms
Citation:
Cseplo
P,
Garami
A,
Solymár
M,
Balasko
M,
Petervari
E and
Szekely
M
(2009). Feeding pattern after intraperitoneal capsaicin desensitization in rats.
Front. Syst. Neurosci.
Conference Abstract:
12th Meeting of the Hungarian Neuroscience Society.
doi: 10.3389/conf.neuro.01.2009.04.006
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Received:
02 Mar 2009;
Published Online:
02 Mar 2009.
*
Correspondence:
Miklos Szekely, University of Pecs, Department of Pathophysiology and Gerontology, Pecs, Hungary, miklos.szekely@aok.pte.hu