Effects of central infusion of CNTF on the energetics of obese mice. Biotelemetric studies.
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1
University of Pécs, Department of Pathophysiology and Gerontology, Hungary
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2
University of Pécs, Department of Applied Life Sciences, Hungary
Ciliary neurotropic factor (CNTF), an inducer of neurogenesis in the hypothalamus, has been shown to cause a permament fall of body mass in mice made obese by a fat-rich diet (DIO), while in genetic obesity this effect is transitory. In the present study energetics of DIO mice has been followed during and after intracerebroventricular (icv) infusion of CNTF (720 ng/day) using ALZET minipump for 7 days. The animals were previously implanted with MINIMITTER biotelemetry transmitter allowing monitoring of abdominal core temperature (Tc) and locomotor avtivity (Act). DIO food induced a rise in body mass by about 40 % over a period of two months and led to a prompt decrease of circadian Tc amplitudes by about 50 % and an increase of 24 hrs Tc averages together with a decrease of Act. Icv infusion of CNTF resulted in an expected reduction of body mass of DIO mice beyond the period of infusion. This response was accompanied by a slight rise in daily averages of Tc together with an increase in Act. The observed permament fall of body mass may have been caused by the increased locomotor activity, but possible changes of food intake – not measured in the present study – could have also contributed to the moderation of obesity of these mice. Further studies are in progress to see, if CNTF had any influence on the energetics of mice fed with standard rodent chow. Supported by the Hungarian National Science Fund (OTKA-T62598) and by an European grant (GVOP-3.2.1-2004-0271/3.0).
Conference:
12th Meeting of the Hungarian Neuroscience Society, Budapest, Hungary, 22 Jan - 24 Jan, 2009.
Presentation Type:
Poster Presentation
Topic:
Homeostatic regulatory mechanisms
Citation:
Solymár
M and
Szelenyi
Z
(2009). Effects of central infusion of CNTF on the energetics of obese mice. Biotelemetric studies..
Front. Syst. Neurosci.
Conference Abstract:
12th Meeting of the Hungarian Neuroscience Society.
doi: 10.3389/conf.neuro.01.2009.04.019
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Received:
25 Feb 2009;
Published Online:
25 Feb 2009.
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Correspondence:
Margit Solymár, University of Pécs, Department of Pathophysiology and Gerontology, Pecs, Hungary, margit.solymar@aok.pte.hu