Oncomodulin-immunopositive axons in parvalbumin knock-out animals: axonal regeneration in the adult central nervous system
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1
University of Szeged, Department of Anatomy, Hungary
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2
University of Fribourg, Unit of Anatomy, Switzerland
Coexistence of GABA and the calcium binding proteins in recently discovered giantic calyciform presynaptic terminals of the reticular thalamic nucleus (Csillik et al, 2002, 2005) raises the question whether or not, GABA and calcium binding proteins are not only structurally but also genetically related to eachother (Csillik et al, 2006). In young adult male homozygous parvalbumin-knockout (PV -/-) mice (Schwaller et al, 1999) we found that GABA immunoreaction of giantic calyciform presynaptic terminals persisted while PV disappeared completely, not only from neuronal parikarya but also from calyciform presynaptic terminals. At the same time, numerous, partly varicous PV immunoreactive axons appeared in the diencephalon, mainly in the lamina medullaris externa surrounding the thalamus.These axons were found to contain oncomodulin or beta-PV, a protein which was known until now to be present in normal mammals only in the Corti organ of the inner ear (Yang et al, 2004) . Newly generated oncomodulin-immunopositive fibres are closely related to oncomodulin-immunoreactive cells scattered in the thalamus. Accordingly, our studies seem to support a recent theory about the origin of oncomodulin from macrophages (Yin et al, 2006), and, nevertheless, prove the involvement of oncomodulin in promoting axonal outgrowth in the diencephalon of parvalbumin-depleted animals. The therapeutical possibility to improve axonal regeneration in the central nervous system by application of oncomodulin presents an unsurpassed challenge for neuropharmacologists and clinical neurologists alike.
Conference:
12th Meeting of the Hungarian Neuroscience Society, Budapest, Hungary, 22 Jan - 24 Jan, 2009.
Presentation Type:
Poster Presentation
Topic:
Pathophysiology and neurology - non-degenerative disorders
Citation:
Csillik
B,
Mihaly
A,
Losonczi
E,
Knyihar
EC and
Schwaller
B
(2009). Oncomodulin-immunopositive axons in parvalbumin knock-out animals: axonal regeneration in the adult central nervous system.
Front. Syst. Neurosci.
Conference Abstract:
12th Meeting of the Hungarian Neuroscience Society.
doi: 10.3389/conf.neuro.01.2009.04.027
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Received:
26 Feb 2009;
Published Online:
26 Feb 2009.
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Correspondence:
Bertalan Csillik, University of Szeged, Department of Anatomy, Szeged, Hungary, csillik@anatomy.szote.u-szeged.hu