Can the Pontine Reticular Formation be the (6Hz) theta generator?
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1
Institute of Biology, Eotvos Lorand University, Hungary
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2
Department of Physiology and Neurobiology, Eotvos Lorand University, Hungary
Pontine Reticular Formation (PRF) as recently has been revealed are involved in the development of generalized convulsive status epilepticus (GCSE). To examine its detailed functional role in GCSE, NMDA was microinjected locally into the PnO (pontine reticular nucleus, oral part) and local field potentials (EEG) was recorded from the frontal and parietal cortex, hippocampus and contralateral PRF. Different concentration of NMDA with both pressure injection (N=4) and microosmotic pump (N=4) induced lesion (100 mmol, N=1), GCSE (10 mmol, N=3) and surprisingly sustained theta (6 Hz) activity (1 mmol, N=5) in the PRF, hippocampus and cortex. As in the current theta model (Vertes and Kocsis, 1997) the PnO only has a tonic influence on the SUM (supramammillary nucleus) where the rhythmic pattern of theta generated, we isolated the SUM from the PnO (N=3) and after the 1 mmol NMDA injection the 6 Hz theta was still revealed in the contralateral PRF. This suggests that the PRF by itself can generate the rhythmic theta pattern. Furthermore, the amplitude of the PRF theta was (>3 times) higher than the hippocampal theta and the theta phase segregation analysis demonstrated its leading role.
Conference:
12th Meeting of the Hungarian Neuroscience Society, Budapest, Hungary, 22 Jan - 24 Jan, 2009.
Presentation Type:
Poster Presentation
Topic:
Developmental neurobiology and subcortical functions
Citation:
Baracskay
P,
Szilagyi
N,
Juhasz
G and
Czurko
A
(2009). Can the Pontine Reticular Formation be the (6Hz) theta generator?.
Front. Syst. Neurosci.
Conference Abstract:
12th Meeting of the Hungarian Neuroscience Society.
doi: 10.3389/conf.neuro.01.2009.04.044
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Received:
27 Feb 2009;
Published Online:
27 Feb 2009.
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Correspondence:
Péter Baracskay, Institute of Biology, Eotvos Lorand University, Budapest, Hungary, baracskay@freemail.hu