Event Abstract

Immunohistochemical study on the rat corpus pineale

  • 1 Department of Anatomy, Semmelweis University, Hungary

The pineal body develops as an evagination of the brain tissue, comprises a by-gone photoreceptive organ and a circumventricular neuroendocrine organ. The present immunohistochemical study investigates the basal lamina (BL) components (laminin, agrin, perlecan, fibronectin), their receptor, the dystrophin-dystroglycan complex(DGC: dystrophin isoforms,β-dystroglycan , utrophin), aquaporins (-4,-9) and cellular markers (S100, neurofilament, GFAP,glutamine synthetase) in the adult rat corpus pineale. The parenchyma is surrounded by a BL, which is fixed by DGC. The pineal vessels proved to be immunoreactive to laminin, although less intensely than the meningeal vessels. An inner, dense and an outer, loose layer of laminin as two separate basal laminae is present. The gap between them contained agrin and perlecan, which, continued although unequally, around the vessels a delicate network forming nests for cells. The vessels were interconnected by wing-like structures. BL components enmeshed the pinalocytes, too. Correspondigly to the elements of BL, the components of its receptor complex, BCG were also distributed along and around the vessls, giving impression of a network. GFAP- or aquaporin-immunostained astrocytes formed contacts on vessels but not so regularly that the course of vessels could be followed. Pineal cells immunostained with glutamine synthetase, S100-protein or neurofilament protein formed thick contacts with vessels. The distribution of same markers, eg. agrin, utrophin, β-dystroglycan, dystrophin was inequal through the body, but did not correspond to the distal and proximal parts of the organ delineated by GFAP and aquaporin.

Supported by OTKA-60930 (holder: Kalman M).

Conference: 12th Meeting of the Hungarian Neuroscience Society, Budapest, Hungary, 22 Jan - 24 Jan, 2009.

Presentation Type: Poster Presentation

Topic: Homeostatic regulatory mechanisms

Citation: Bagyura Z, Pócsai K and Kalman M (2009). Immunohistochemical study on the rat corpus pineale. Front. Syst. Neurosci. Conference Abstract: 12th Meeting of the Hungarian Neuroscience Society. doi: 10.3389/conf.neuro.01.2009.04.105

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Received: 03 Mar 2009; Published Online: 03 Mar 2009.

* Correspondence: Zsolt Bagyura, Department of Anatomy, Semmelweis University, Budapest, Hungary, bagyura@gmail.com