Investigation of slow cortical rhythm in sleep deprived rats
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1
Department of Physiology and Neurobiology, Eötvös Loránd University, Hungary
Sleep - the most obvious example of biological rhythms - has homeostatic functions as well: after sleep deprivation deep sleep loss is compensated by an increase in its length and intensity. Intensity seems to be related to the power of the delta frequency band of the EEG which is generated by the slow oscillation of the pyramidal cell’s membrane potential. The increase of delta power after sleep deprivation can be the consequence of 1,: higher synchronization of pyramidal cell populations, 2,: longer hyperpolarized downstates, 3,: more frequent hyperpolarized states, 4,:deeper hyperpolarization of pyramidal cells. To investigate these possibilities male SPRD rats with surgically implanted concentric bipolar transcortical electrodes were sleep-deprived for 6 hours. EEG and multiunit activity were registered before and after deprivation. EEG downstates were isolated and their frequency as well as the length and amplitude of the averaged downstate shape were calculated for every hour. Sleep-wake state was also defined by calculating the delta power, the theta/delta ratio and the muscle tone variance in every 4 seconds. The biggest change after deprivation was a large enhancement of downstate frequency, which was significant for four hours after SD. The shape of the averaged downstates was slightly changed: small but significant enlargement of the amplitude was seen in the first two hours. No significant change in the average downstate duration was present. These results indicate higher hyperpolarization and/or synchronization of pyramidal cells and more intensive emergence of downstate inducing (but not maintaining) effects.
Conference:
12th Meeting of the Hungarian Neuroscience Society, Budapest, Hungary, 22 Jan - 24 Jan, 2009.
Presentation Type:
Poster Presentation
Topic:
Homeostatic regulatory mechanisms
Citation:
Hajnik
T,
Nagy
B,
Toth
A and
Detari
L
(2009). Investigation of slow cortical rhythm in sleep deprived rats.
Front. Syst. Neurosci.
Conference Abstract:
12th Meeting of the Hungarian Neuroscience Society.
doi: 10.3389/conf.neuro.01.2009.04.109
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Received:
03 Mar 2009;
Published Online:
03 Mar 2009.
*
Correspondence:
Tünde Hajnik, Department of Physiology and Neurobiology, Eötvös Loránd University, Budapest, Hungary, tucsok@tucsok.hu