Niosomes as drug targeting systems
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1
Institute of Biophysics, Biological Research Center, Hungary Academy of Sciences , Hungary
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2
Department of Pharmaceutical Technology, University of Szeged, Hungary
Niosomes are bilayered vesicles of non-ionic surfactants with some structural similarity to unilamellar phospholipid vesicles, liposomes. These nanoparticles are formed spontaneously from the self-assembly of non-ionic amphiphiles in aqueous media due to physical agitation or heat. Therefore hollow spheres can be made, which are able to encapsulate aqueous solutes and serve as potential drug carriers. Inserting specific transporter or receptor ligands into their wall can result in targeting the niosomes. The aim of the study was to test the suitability of niosomes for the entrapment of a model drug and for the targeted release through the blood-brain barrier. Different production methods and twelve formulation compositions, all from biocompatible and biodegradable materials, were examined. To characterise the niosomes image analysis by atomic force microscopy, particle size analysis, zeta potential measurements, drug content and encapsulation efficiency were evaluated. The parameter effects on drug liberation, especially the influence of the changes in dependent variables on the product structure and physicochemical parameters were examined. The physicochemical, structural and imaging methods were used in parallel with in vivo experiments in rats. The structure of the niosomes, as well as the changes that occur in the structure due to the ingredients, the production methods and with the addition of surface ligands were assessed using thermoanalytical and spectroscopy measurements. Our results indicate that niosomes with an average hydrodynamical size of 200 nm can be used for targeting hydrophilic molecules across the blood-brain barrier.
Conference:
12th Meeting of the Hungarian Neuroscience Society, Budapest, Hungary, 22 Jan - 24 Jan, 2009.
Presentation Type:
Poster Presentation
Topic:
Pathophysiology and neurology - non-degenerative disorders
Citation:
Horvat
S,
Sipos
P,
Kis
L,
Toth
A,
Eros
I,
Szabo
PR and
Deli
M
(2009). Niosomes as drug targeting systems.
Front. Syst. Neurosci.
Conference Abstract:
12th Meeting of the Hungarian Neuroscience Society.
doi: 10.3389/conf.neuro.01.2009.04.253
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Received:
16 Mar 2009;
Published Online:
16 Mar 2009.
*
Correspondence:
Mária Deli, Institute of Biophysics, Biological Research Center, Hungary Academy of Sciences, Szeged, Hungary, deli.maria@brc.hu