Altered processing in orbitofrontal cortex activity in monoarthritic rats during a rodent gambling task
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1
Faculdade de Medicina, Universidade do Porto, Instituto de Histologia e Embriologia, Portugal
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2
Universidade do Porto, IBMC-Instituto de Biologia Celular e Molecular, Portugal
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3
Faculdade de Medicina, Universidade do Porto, Laboratorio de Biologia Molecular e Celular, Portugal
The orbitofrontal cortex (OFC) is fundamental for the update of reward value in decision making tasks in humans and animals. Previous works in rats have shown that lesions of the OFC, as well as chronic pain lead to impairment in the Rodent Gambling Task akin to the Iowa Gambling Task (Bechara et al., 1994). Here we used multielectrode recordings to study orbitofrontal cortex activity in rats performing this task during control and chronic pain conditions. As expected, control animals developed preference for low risk choices while monoarthritic rats developed preference for high risk choices. Neuronal activity showed that control animals present a higher proportion of cells that differentially fire for high and low risk choices during the whole task, while monoarthritic animals only present this differential activity in the beginning of the task. Comparison of neuronal responses to rewards showed that control animals presented a higher proportion of cells with different firing rates for high and low risk rewards, but that the pain group presented an increased number of cells that differentially fired for rewarded and non rewarded trials in the low risk lever. These results show for the first time altered orbitofrontal cortex processing during decision-making deficits in chronic pain conditions and support the notion that chronic pain alters the reward/aversion system.
Supported by FCT Grant – SFRH/BD/24383/2005; BIAL 126/08
Conference:
11th Meeting of the Portuguese Society for Neuroscience, Braga, Portugal, 4 Jun - 6 Jun, 2009.
Presentation Type:
Oral Presentation
Topic:
Symposium 5 – Pain
Citation:
Pais-Vieira
M,
Lima
D and
Galhardo
V
(2009). Altered processing in orbitofrontal cortex activity in monoarthritic rats during a rodent gambling task.
Front. Neurosci.
Conference Abstract:
11th Meeting of the Portuguese Society for Neuroscience.
doi: 10.3389/conf.neuro.01.2009.11.030
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Received:
06 Aug 2009;
Published Online:
06 Aug 2009.
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Correspondence:
Miguel Pais-Vieira, Faculdade de Medicina, Universidade do Porto, Instituto de Histologia e Embriologia, Porto, Portugal, msvieira@med.up.pt