Stability of Hippocampal Place Cells Activity After Peripheral
Nerve Injury: A Study Based on Chronic Extracellular
Multichannel Recordings
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1
Universidade do Porto, Instituto de Biologia Molecular e Celular (IBMC), Unidade de Morfofisiologia do Sistema Somato-sensitivo, Portugal
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2
Faculdade de Medicina, Universidade do Porto, Instituto de Histologia e Embriologia, Portugal
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3
Faculdade de Medicina, Universidade do Porto, Laboratorio de Biologia Celular, Portugal
The hippocampus is important for processing the spatial layout and configural representation of an environment. In addition, it has been shown that the rat hippocampal CA1 pyramidal complex-spike “place” cells respond to persistent noxious activation. The aim of the present study was to evaluate the effects of a peripheral neuropathic pain condition on the properties of spatial CA1 hippocampal place cells. Our results include extracelluar single-unit data from 6 adult male Sprague-Dawley rats trained to alternate on a U- shaped runway for food reinforcement. A total of 54 place cells were recorded from CA1 in 4 SNI (n=36) and 2 SHAM (n=18) animals. Spatial firing and place field characteristics of the cells were examined before (10 days) and after (21 days) peripheral nerve injury (SNI). The findings showed an increase of the number of place fields encoded per cell and an increase of the place field size (expansion) after nerve injury. In addition, the infield coherence increases for the SNI-group and amount of spatial information (specificity) content that a single spike conveyed about the animal location decrease over time. However, other measures of spatial tuning (e. g. infield firing rate, firing peak and number of spikes) were unchanged between the two experimental groups. The current study suggests that there is a relative instability of hippocampal place cells across the installation of the peripheral pain condition in a well-trained task.
Supported by FCT Grant- SFRH/BD/42500/2007 and BIAL Project-126/08.
Conference:
11th Meeting of the Portuguese Society for Neuroscience, Braga, Portugal, 4 Jun - 6 Jun, 2009.
Presentation Type:
Poster Presentation
Citation:
Cardoso-Cruz
H,
Lima
D and
Galhardo
V
(2009). Stability of Hippocampal Place Cells Activity After Peripheral
Nerve Injury: A Study Based on Chronic Extracellular
Multichannel Recordings.
Front. Neurosci.
Conference Abstract:
11th Meeting of the Portuguese Society for Neuroscience.
doi: 10.3389/conf.neuro.01.2009.11.058
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Received:
07 Aug 2009;
Published Online:
07 Aug 2009.
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Correspondence:
Helder Cardoso-Cruz, Universidade do Porto, Instituto de Biologia Molecular e Celular (IBMC), Unidade de Morfofisiologia do Sistema Somato-sensitivo, Porto, Portugal, hcruz@ibmc.up.pt