Neuropeptide Y stimulates proliferation, migration and differentiation of neural precursors from the subventricular zone in adult mice: Potential therapeutic application for Huntington's disease
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1
Universite de Poitiers, PBS - UMR 6187, France
The neuropeptide Y (NPY) is widely expressed in the central nervous system and has been shown to stimulate neurogenesis in the hippocampus and the olfactory epithelium. Here, we demonstrate that intracerebroventricular injection of NPY stimulates proliferation of neural stem cells in the mice subventricular zone (SVZ), one the most neurogenic areas of the brain. Newly generated neuroblasts migrate through the rostral migratory stream to the olfactory bulb and directly to the striatum, as evidenced by BrdU labeling and cell phenotyping. Using knockout mice, specific NPY receptor agonists and antagonists, we report that this neuroproliferative effect is mediated by the Y1 receptor subtype that we found to be highly expressed in the SVZ both at the mRNA and protein levels. Our data suggest that stimulating endogenous SVZ neural stem cells by NPY may be of a potential interest in cell replacement based therapies of neurodegenerative diseases affecting the striatum such as Huntington’s disease.
Conference:
3rd Mediterranean Conference of Neuroscience , Alexandria, Egypt, 13 Dec - 16 Dec, 2009.
Presentation Type:
Oral Presentation
Topic:
Symposium 03 – Cellular regulation of adult-born neurons and their stem cells
Citation:
Gaillard
A
(2009). Neuropeptide Y stimulates proliferation, migration and differentiation of neural precursors from the subventricular zone in adult mice: Potential therapeutic application for Huntington's disease.
Front. Neurosci.
Conference Abstract:
3rd Mediterranean Conference of Neuroscience .
doi: 10.3389/conf.neuro.01.2009.16.016
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Received:
18 Nov 2009;
Published Online:
18 Nov 2009.
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Correspondence:
Afsaneh Gaillard, Universite de Poitiers, PBS - UMR 6187, 86022 Poitiers, France, Afsaneh.Gaillard@univ-poitiers.fr