Differences in the behavioral effects of oxytocin and carbetocin after their peripheral application to Wistar rats
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1
Charles University , Laboratory of Neuropharmacology, Department of Medical Biochemistry, 1st Faculty of Medicine, Czechia
Oxytocin (OXY) is a neurohypophyseal nonapeptide, which has primarily the peripheral effects during parturation and lactation. In the brain OXY acts as a neurotransmitter or neuromodulator and plays, a prominent role in several central functions, like behavior, memory, learning, grooming etc. A number of OXY analogs have been designed as therapeutic substitutes with changed uterotonic activities. Carbetocin (CBT; deamino-1-monocarba-[2-O-methyltyrosine]-oxytocin) was prepared as a long-acting OXY analog to control postpartum bleeding. Peripheral administration of OXY is known to produce behavioral effects; however, there are very limited experimental data on the central effects of CBT. The aim of this study was to compare the length of behavioral effects of OXY and CBT. Male Wistar rats were used. Spontaneous behavior was tested in circular open-field arena with 150 cm diameter. Behavioral parameters were recorded by AnyMaze software (Stoelting Co, USA). OXY and CBT (Polypeptides GmbH, Czech Republic) were given i.p. 60 min before behavioral test and repeatedly tested in several following days. While OXY produced reduction of exploratory activity and increased grooming time, CBT had slight increasing effect on the exploratory activity and revealed no effect on grooming. The exploratory effect of CBT survives for several days while the effect of OXY was not long lasting. Our results support the possibility of using CBT in various psychic disorders like autism etc.
Acknowledgements: Supported by MSM 0021620806.
Keywords:
Behavior,
carbetocin,
exploration,
Grooming,
Oxytocin
Conference:
3rd Mediterranean Conference of Neuroscience , Alexandria, Egypt, 13 Dec - 16 Dec, 2009.
Presentation Type:
Poster Presentation
Topic:
Cognition
Citation:
Klenerova
V and
Hynie
S
(2009). Differences in the behavioral effects of oxytocin and carbetocin after their peripheral application to Wistar rats.
Front. Neurosci.
Conference Abstract:
3rd Mediterranean Conference of Neuroscience .
doi: 10.3389/conf.neuro.01.2009.16.140
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Received:
25 Nov 2009;
Published Online:
25 Nov 2009.
*
Correspondence:
Vera Klenerova, Charles University, Laboratory of Neuropharmacology, Department of Medical Biochemistry, 1st Faculty of Medicine, Prague, Czechia, vera.klenerova@lf1.cuni.cz