Impact of lead on the circadian rhythm of locomotor activity and prophylactic effect of melatonin and 5-metoxytryptophol
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1
University Mohammed V Agdal , Group of research on biological rhythms, Department of Biology, Faculty of Science, Morocco
Purpose: we attempted to demonstrate the impact of lead on circadian locomotor activity and the protective effect of melatonin and 5 – methoxytryptophol against the toxic properties of lead.
Methods: four groups of young’s rats were used (control, lead acetate – treated [1 mg/animal], lead acetate plus melatonin [25 µg/kg], and lead acetate plus 5-metoxytryptophol [25 µg/kg]). We use the Actimetry system to record the locomotor activity.
Results: we observed a decreased in locomotor’s activity and the synchronization of circadian rhythm of this activity by light is deeply disturbed by Lead, which makes it possible to suggest the deterioration of the transmission of photic information towards the suprachiasmatic nucleus. Moreover, Melatonin as well as 5 –methoxytryptophol seems to be protective.
Conclusions: Lead has a chronobiotic effect. The expression of locomotor activity rhythm and its synchronization by light is partially or totally restore by melatonin and 5 – methoxytryptophol.
Conference:
3rd Mediterranean Conference of Neuroscience , Alexandria, Egypt, 13 Dec - 16 Dec, 2009.
Presentation Type:
Poster Presentation
Topic:
Imaging & Neuroendocrinology
Citation:
Ouzir
M,
Moussaouiti
RE and
Lakhdar-Ghazal
N
(2009). Impact of lead on the circadian rhythm of locomotor activity and prophylactic effect of melatonin and 5-metoxytryptophol.
Front. Neurosci.
Conference Abstract:
3rd Mediterranean Conference of Neuroscience .
doi: 10.3389/conf.neuro.01.2009.16.161
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Received:
26 Nov 2009;
Published Online:
26 Nov 2009.
*
Correspondence:
Mounir Ouzir, University Mohammed V Agdal, Group of research on biological rhythms, Department of Biology, Faculty of Science, Halifax, Nova Scotia, Morocco, m.ouzir@gmail.com