Neuroanatomical aspects of the memory-improving effect of intracranial self-stimulation at the lateral hypothalamus: a c-Fos study
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1
Universitat Autònoma de Barcelona, Institut de Neurociències, Spain
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2
Universitat de Girona, Departament de Biologia Cellular, Spain
In our previous research we have observed that intracranial self-stimulation (ICSS) at the lateral hypothalamus (LH) facilitates both implicit and explicit memory, in rats. This effect was specially strong when 2500 trains of ICSS were administered after one acquisition session of just 5 acquisition trials of two-way active avoidance conditioning (TWAA) and the retention was evaluated 48 hours later [1]. With the same paradigm, we now evaluate changes in c-Fos expression in brain regions implicated in learning and memory that could be related to this facilitative effect of ICSS.
The following experimental groups were used: (a) ICSS; (b) TWAA acquisition; (c) TWAA acquisition + ICSS; (d) TWAA acquisition + TWAA retention; (e) TWAA acquisition + ICSS + TWAA retention; (f) Control Naïve; (g) Control Sham (with electrode implantation and manipulated as “a” but without ICSS). Rats were sacrificed 70 minutes after the respective last experimental condition. Results: (1) the facilitative effect of ICSS on 48h retention of TWAA was confirmed; (2) avoidance conditioning increased c-Fos expression in CA1 and CA3; (3) ICSS treatment alone caused a bilateral increase in c-Fos expression in CA1, CA3, DGmb, DGlb (Dentatus Gyrus, medial and lateral blade), Dorsal Striatum (DStr), and LH (higher in the ipsilateral hemisphere); (4) ICSS applied after TWAA caused a higher c-Fos expression in CA3 compared to the training alone condition (without ICSS), and a tendency in DGlb. These results suggest that the facilitative effects of ICSS on memory could be mediated by the post-training activation of specific hippocampal regions such as CA3.
References
1. Ruiz-Medina et al. 2008. Neurobiol Learn Memory 89,574-581.
Conference:
41st European Brain and Behaviour Society Meeting, Rhodes Island, Greece, 13 Sep - 18 Sep, 2009.
Presentation Type:
Poster Presentation
Topic:
Poster presentations
Citation:
Aldavert-Vera
L,
Huguet
G,
Costa-Miserachs
D,
Segura
M,
Kádár
E,
Morgado-Bernal
I and
Segura-Torres
P
(2009). Neuroanatomical aspects of the memory-improving effect of intracranial self-stimulation at the lateral hypothalamus: a c-Fos study.
Conference Abstract:
41st European Brain and Behaviour Society Meeting.
doi: 10.3389/conf.neuro.08.2009.09.080
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Received:
05 Jun 2009;
Published Online:
05 Jun 2009.
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Correspondence:
Laura Aldavert-Vera, Universitat Autònoma de Barcelona, Institut de Neurociències, Barcelona, Spain, laura.aldavert@uab.cat