Event Abstract

Delayed aging has a cost: reduced fertility, redirection of maternal activities and earlier onset of puberty in p66Shc-/- mice

  • 1 Istituto Superiore di Sanita, Department of Cell Biology and Neurosciences, Italy
  • 2 European Institute of Oncology, Division of Experimental Oncology, Italy
  • 3 Leiden University, Leiden/Amsterdam Center for Drug Research, Netherlands

Targeted mutation of the p66Shc gene, in mice, results in reduced oxidative stress, increased metabolic rate and in an increase in lifespan associated to a delayed aging without any apparent “side effect”. The antagonistic pleiotropy theory of aging predicts that for each immediate benefit there is a price to pay later in life, for example a negative correlation between longevity and reproductive success has been reported. Main aim of this study was to investigate whether the increased lifespan in the p66Shc-/- mice has a cost in terms of their overall fitness. To this purpose we looked at repeated breeding cycles, breeding under stressful conditions, mean number of pups per nest and time of the onset of puberty. Since p66Shc-/- mice are characterized by a decreased emotionality we also investigated whether this characteristic may be mediated by changes in early environmental factors, such as maternal care. To this purpose, we tested the effects of the p66Shc deletion on maternal behavior from postnatal day 1 to 8. P66Shc-/- mice showed an overall earlier onset of puberty in addition to a reduced fertility both over repeated breeding cycles and under challenging stressful situations; mean number of pups did not differ between the two genotypes. A redirection of maternal behavior was observed in mutant mice as a function of their feeding pattern, which might account for the anticipated onset puberty observed in the offspring. Taken together our results show that p66Shc is important for optimal reproductive success. The lack of the gene is able to affect sexual maturation, an effect possibly mediated by changes in maternal care.

Funded by Italian Ministry of Health (grant on Neurodegenerative Diseases - ex art. 56 - to F.C., L.M. and E.A.), Marie Curie fellowship (grant on “The Genetic Basis of Disease; Stress-Responsive Genes in Brain during Health and Disease” to A.B.).

Conference: 41st European Brain and Behaviour Society Meeting, Rhodes Island, Greece, 13 Sep - 18 Sep, 2009.

Presentation Type: Poster Presentation

Topic: Poster presentations

Citation: Berry A, Giorgio M, Trinei M, Giuseppe-Pelicci P, De Kloet ER, Alleva E and Cirulli F (2009). Delayed aging has a cost: reduced fertility, redirection of maternal activities and earlier onset of puberty in p66Shc-/- mice. Conference Abstract: 41st European Brain and Behaviour Society Meeting. doi: 10.3389/conf.neuro.08.2009.09.091

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Received: 08 Jun 2009; Published Online: 08 Jun 2009.

* Correspondence: Alessandra Berry, Istituto Superiore di Sanita, Department of Cell Biology and Neurosciences, Rome, Italy, alessandra.berry@iss.it