Acupuncture as an alternative to stimulate salivary secretion in rats
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1
Kyung Hee University, Acupuncture and Meridian Science Research Center, Republic of Korea
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2
Kyung Hee University, College of Oriental Medicine, Republic of Korea
Aquaporins (AQPs) are membrane proteins involved in regulating water transport in many fluid-transporting organs. Among them, the salivary gland is typical to be affected most severely by AQPs. Because the conventional drugs to stimulate salivary glands are only partially effective, the acupuncture is exploited as an alternative therapy to stimulate salivary secretion in the rat thirst model in which the muscarinic receptor was blocked by 4-diphenylacetoxy-N-methylpiperidine (4-DAMP). When the acupuncture was administered to the rats, the suppression of salivary secretion induced by intraperitoneal injection of 4-DAMP was recovered. The expression of aquaporin-5 (AQP-5) was also investigated to verify the acupuncture effect on regulating salivary secretion from submandibular gland at the molecular level. Compared with those in non-acupoint-treated rats, the acupuncture significantly recovered the expression levels of mRNA and protein of AQP-5 in the parotid glands. These results suggested that the acupuncture treatment modulated the salivary secretion by stimulating the muscarinic M3 receptor of salivary glands, and its mechanism was closely related to the AQP-5 expression in the parotid glands.
This work was supported by the Korea Science and Engineering Foundation (KOSEF) grant funded by the Korea government (MEST) (R11-2005-014).
Conference:
41st European Brain and Behaviour Society Meeting, Rhodes Island, Greece, 13 Sep - 18 Sep, 2009.
Presentation Type:
Poster Presentation
Topic:
Poster presentations
Citation:
Min-Choi
S,
Bong-Jun
S,
Jin-Sung
K,
Hye-Jung
L and
Dae-Hyun
H
(2009). Acupuncture as an alternative to stimulate salivary secretion in rats.
Conference Abstract:
41st European Brain and Behaviour Society Meeting.
doi: 10.3389/conf.neuro.08.2009.09.113
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Received:
08 Jun 2009;
Published Online:
08 Jun 2009.
*
Correspondence:
Soo Min-Choi, Kyung Hee University, Acupuncture and Meridian Science Research Center, Seoul, Republic of Korea, choism999@nave.com