The neuroprotective effect of acupuncture at GB34 in a MPTP-induced Parkinson's disease mouse model
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1
Pusan National University, School of Oriental Medicine, Republic of Korea
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2
Kyung Hee University, Acupuncture and Meridian Science Research Center, Republic of Korea
Acupuncture is a technique of inserting and manipulating sharp filiform needles, which is frequently used for Parkinson’s disease (PD) in Korean medicine. There were several reports for the neuroprotective effect of acupuncture for PD, but it is still unknown whether acupuncture stimulation can alleviate behavioral troubles in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced PD mice model. Using pole test, we investigated the behavioral changes and neuroprotective effects of acupuncture stimulation on GB34, known to be effective in motor dysfunction, from MPTP toxicity. Twelve weeks old male C57BL/6 mice were injected with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP, 30 mg/kg/day) intraperitoneally for 5 days, then they received acupuncture stimulation on GB34 or SI3 acupoint once a day for 12 consecutive days from 2 hours after the first MPTP injection. Pole test was performed 2 hours after the last acupuncture stimulation, then the mice were perfused immediately and the MPTP-induced neuronal destruction in substania nigra of the mice was measured by tyrosine hydroxylase immunohistochemistry. In results, acupuncture stimulation on GB34 improved the MPTP-induced behavioral troubles in pole test and rescued MPTP-induced dopaminergic neurodegeneration. These results suggest that acupuncture stimulation on GB34 alleviates the behavioral troubles by protecting dopaminergic neuronal damage in the MPTP-induced mouse PD model.
Conference:
41st European Brain and Behaviour Society Meeting, Rhodes Island, Greece, 13 Sep - 18 Sep, 2009.
Presentation Type:
Poster Presentation
Topic:
Poster presentations
Citation:
Seung-Tae
K,
Woongjoon
M,
Seung-Nam
K,
Hyejung
L and
Hi-Joon
P
(2009). The neuroprotective effect of acupuncture at GB34 in a MPTP-induced Parkinson's disease mouse model.
Conference Abstract:
41st European Brain and Behaviour Society Meeting.
doi: 10.3389/conf.neuro.08.2009.09.297
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Received:
15 Jun 2009;
Published Online:
15 Jun 2009.
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Correspondence:
Kim Seung-Tae, Pusan National University, School of Oriental Medicine, Yangsan, Republic of Korea, kimst@pusan.ac.kr