Correlation of slow spontaneous neuronal fluctuations across hemispheres in human sensory cortex
Yuval
Nir1*,
R.
Mukamel2,
I.
Dinstein3,
E.
Privman4,
M.
Harel1,
L.
Fisch1,
H.
Gelbard-Sagiv1,
S.
Kipervasser5, 6,
F.
Andelman7,
M.
Neufeld5, 6,
U.
Kramer5, 7,
A.
Arieli1,
I.
Fried5, 7, 8 and
Rafael
Malach1
-
1
Department of Neurobiology, Weizmann Institute of Science, Israel
-
2
University of California Los Angeles (UCLA), Ahmanson Lovelace Brain Mapping Center, Neuropsychiatric Institute, David Geffen School of Medicine, United States
-
3
Center for Neural Science, New York University, United States
-
4
School of Computer Science, Sackler Faculty of Exact Sciences, Tel Aviv University, Israel
-
5
Sackler School of Medicine, Tel Aviv University, Israel
-
6
Electroencephalography and Epilepsy Unit, Department of Neurology, Tel Aviv Medical Center, Israel
-
7
Functional Neurosurgery Unit, Tel Aviv Medical Center, Tel Aviv, Israel, Israel
-
8
University of California (UCLA), Division of Neurosurgery, David Geffen School of Medicine, and Semel Institute for Neuroscience and , United States
Recent functional magnetic resonance imaging (fMRI) studies reveal the presence of spontaneous fluctuations of activity in human sensory cortex emerging in the complete absence of external stimuli or task. Such fluctuations show remarkable selectivity for functional networks, coherence across large cortical distances and across hemispheres, yet it is currently unknown what neuronal dynamics may underlie this spontaneous activity in the human brain. We studied this question by combining bilateral single-unit, local field potentials (LFPs), and intra-cranial electrocorticography (ECoG) recordings in patients undergoing clinical monitoring. We found very slow (<0.1Hz, following 1/f profiles) spontaneous waves of neuronal activity exhibiting significant interhemispheric correlations. These correlated waves were evident mainly in neuronal firing rates and in gamma (40-100Hz) LFP power modulations. A comparison of wake vs. REM and stage II sleep states revealed that the interhemispheric correlations were significantly enhanced during sleep. This enhancement supports the notion that the spontaneous neuronal activity does not play a role in willful and intentional cognitive processes. Multiple intra-cranial ECoG recordings replicated the inter-hemispheric correlations in gamma power and revealed a clear selectivity for functional networks. Our results suggest that slow, low-amplitude modulations in firing rate and gamma LFP power are likely candidates for the neuronal dynamics underlying the well-known spontaneous fMRI fluctuations in human sensory cortex. Supported by ISF and Benozyio grant to R. Malach and US Israel BSF and WIS-TASMC grant to R. Malach and I. Fried.
Conference:
10th International Conference on Cognitive Neuroscience, Bodrum, Türkiye, 1 Sep - 5 Sep, 2008.
Presentation Type:
Oral Presentation
Topic:
Symposium 14: Multimodal Studies of Oscillations
Citation:
Nir
Y,
Mukamel
R,
Dinstein
I,
Privman
E,
Harel
M,
Fisch
L,
Gelbard-Sagiv
H,
Kipervasser
S,
Andelman
F,
Neufeld
M,
Kramer
U,
Arieli
A,
Fried
I and
Malach
R
(2008). Correlation of slow spontaneous neuronal fluctuations across hemispheres in human sensory cortex.
Conference Abstract:
10th International Conference on Cognitive Neuroscience.
doi: 10.3389/conf.neuro.09.2009.01.066
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Received:
01 Dec 2008;
Published Online:
01 Dec 2008.
*
Correspondence:
Yuval Nir, Department of Neurobiology, Weizmann Institute of Science, Rehovot, Israel, yuval.nir@weizmann.ac.il