The novelty P3 in the subthalamic nucleus (STN): An intracerebral recording study
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1
Masaryk University, Czechia
Purpose: The appearance of a novelty P3 in the STN was studied. A recent study demonstrated that a P3 evoked by an executive function task but not by a simple oddball was generated in the STN (Baláž, 2008). Methods: The event- related potentials were analysed in five Parkinson´s disease patients with externalised deep brain stimulation electrodes localized bilaterally in the STN and within its immediate vicinity. The novelty protocol (Polich 2007): The frequent (70%) stimuli (without reaction): small blue circle; the target (15%, with motor response - pressing a button): larger blue circle; the distracter (15%, without reaction): checkboard. Results: A far field P3b wave (after target stimuli) was found in four of five patients bilaterally. The P3a (after distractor stimuli) was detected constantly on both sides in all recordings. In two subjects an amplitude gradient was observed indicating a possible source of P3a within the STN. The amplitude of the P3b was significantly smaller than the amplitude of the P3a waves. Surprisingly in three subjects the latency of the P3a was longer than the latency of the P3b. Conclusion: The novel but not standard oddball stimuli could be processed also in the STN together with other cortical areas. The involvement of STN in cognitive activities is selective and specific. The latency prolongation of the P3a within the STN is probably caused by some pathophysiological mechanism of Parkinson´s disease.
Conference:
10th International Conference on Cognitive Neuroscience, Bodrum, Türkiye, 1 Sep - 5 Sep, 2008.
Presentation Type:
Poster Presentation
Topic:
Neuroinformatics of Cognition
Citation:
Bočková
M,
Baláž
M and
Rektor
I
(2008). The novelty P3 in the subthalamic nucleus (STN): An intracerebral recording study.
Conference Abstract:
10th International Conference on Cognitive Neuroscience.
doi: 10.3389/conf.neuro.09.2009.01.290
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Received:
09 Dec 2008;
Published Online:
09 Dec 2008.
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Correspondence:
Martina Bočková, Masaryk University, Brno, Czechia, haskova@bii.cz