The brain response of emotional ambivalence on the emotional discrimination in schizophrenia
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1
Yonsei University College of Medicine, Republic of Korea
The aim of this study is to investigate the influence of emotional stimulus on the emotional discrimination in the patient with schizophrenia. The participants were eleven right-handed healthy volunteers and eleven right-handed patients with schizophrenia. The stimuli composed of visual stimuli with ambivalent emotional condition, positive emotional condition, negative emotional condition, neutral condition and null trials that were presented in an event-related design. The ambivalent emotional condition consisted of positive and negative picture pair. On the contrary, in the positive, the negative and the neutral condition, stimuli under the same condition were presented by pair. All stimuli were presented for 3.5 seconds and the participants were asked to discriminate emotional valence that positive, negative and not positive and not negative. We used a 3T fMRI system for the acquisition of a T2*-weighted gradient echo planar imaging (EPI) sequence sensitive to the BOLD contrast [TR = 2000 ms, TE = 35 ms, flip angle 90°, with matrix of 64ⅹ64 and field of view of 220 mm]. We statistically analyzed event-related data by contrasting the ambivalent-minus-neutral, the positive-minus-neural and the negative-minus-neutral for all participants. In the ambivalent-minus-neutral (ambivalent condition), the normal participants showed brain activations in the inferior temporal gyrus, the bilateral cerebellum, the middle frontal gyrus, the fusiform gyrus (uncorrected p<0.001, cluster size>50). However, the patients with schizophrenia showed brain activations in the precuneus and the bilateral middle temporal gyrus. In the positive-minus-neural (positive condition), the normal participants revealed brain activation in the bilateral inferior temporal gyrus, the thalamus, the lingual gyrus. The patients with schizophrenia revealed brain activation in the bilateral thalamus and the bilateral paracingulate gyrus in positive condition. In the negative-minus-neutral (negative condition), normal participants showed brain activations in the precuneus, the middle frontal gyrus, the supplementary motor area, the postcentral gyrus, the thalamus, the amygdale. The patients with schizophrenia showed brain activations in the insula, the hippocampus and the posterior cingulate gyrus. In this study, we found differences between the patients with schizophrenia and normal participants in the ambivalent condition. In the ambivalent condition, normal participants showed brain activation in the bilateral cerebellum and frontal gyrus. However, the patients with schizophrenia showed brain activations in the precuneus and the bilateral middle temporal gyrus during experiencing emotional conflict. In the positive condition, all participants showed activation in the emotional-related region including the precuneus and the thalamus. Also, in the negative condition, they showed brain activation in regions related to emotion including the thalamus, the amygdale and the cingulate gyrus.
Conference:
10th International Conference on Cognitive Neuroscience, Bodrum, Türkiye, 1 Sep - 5 Sep, 2008.
Presentation Type:
Poster Presentation
Topic:
Neuropsychiatric Disorders
Citation:
Kim
J,
Park
H,
Park
I,
Chun
J and
Choi
D
(2008). The brain response of emotional ambivalence on the emotional discrimination in schizophrenia.
Conference Abstract:
10th International Conference on Cognitive Neuroscience.
doi: 10.3389/conf.neuro.09.2009.01.411
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Received:
17 Dec 2008;
Published Online:
17 Dec 2008.
*
Correspondence:
Jae-Jin Kim, Yonsei University College of Medicine, Seoul, Republic of Korea, jaejkim@yuhs.ac