Adaptation, stimulus-specific adaptation in auditory cortex, and MMN
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1
Department of Neurobiology and the ICNC, Hebrew University, Israel
Neuronal adaptation is usually thought of as a fatigue of the spike generation mechanism, for example due to accumulation of sodium channel inactivation in the initial segment of the axon or to the activation of hyperpolarizing currents in the soma. Such mechanisms cannot account for stimulus-specific adaptation (SSA), since they would affect the responses to all stimuli to the same degree. Adaptation can however serve as a building block for more complex circuits that can show SSA, the simplest being a widely tuned neuron that sums the activity of multiple narrowly tuned, partially overlapping, adapting inputs. Synaptic depression in particular is a common mechanism for adaptation in the nervous system, and networks of neurons with synaptic depression show non-trivial population dynamics which might be used to generate SSA. Thus, while SSA cannot be explained by the simplest models of adaptation, it can conceivably be generated by using adaptation mechanisms in an appropriate configuration. Although SSA is not MMN, both share a number of important features, suggesting that adaptation mechanisms could play an important role in shaping MMN. Models of MMN should avoid the trap of considering the unprocessed sound sequence as the input to the generator of the MMN. In particular, the auditory system abounds with distributed 'surprise' signals, which may be processed to form MMN.
Conference:
MMN 09
Fifth Conference on Mismatch Negativity (MMN) and its Clinical and Scientific Applications, Budapest, Hungary, 4 Apr - 7 Apr, 2009.
Presentation Type:
Oral Presentation
Topic:
Workshop 2: The role of adaptation in deviance detection
Citation:
Nelken
I
(2009). Adaptation, stimulus-specific adaptation in auditory cortex, and MMN.
Conference Abstract:
MMN 09
Fifth Conference on Mismatch Negativity (MMN) and its Clinical and Scientific Applications.
doi: 10.3389/conf.neuro.09.2009.05.012
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Received:
19 Mar 2009;
Published Online:
19 Mar 2009.
*
Correspondence:
Israel Nelken, Department of Neurobiology and the ICNC, Hebrew University, Jerusalem, Israel, israel.nelken@mail.huji.ac.il