Event Abstract

Spatiotemporal Signatures Of Large-Scale Synfire Chains For Speech Processing As Revealed By MEG

  • 1 INSERM, Ecole Normale Superieure, United Kingdom

We report a new brain signature of memory trace activation in the human brain revealed by magnetoencephalography and distributed source localization. Spatiotemporal patterns of cortical activation can be picked up in the time course of source images underlying magnetic brain responses to speech and noise stimuli, especially the generators of the magnetic Mismatch Negativity. We found that acoustic signals perceived as speech elicited a well-defined spatiotemporal pattern of sequential activation of superior-temporal and inferior-frontal cortex, whereas the same identical stimuli, when perceived as noise, did not elicit temporally structured activation. Strength of local sources constituting large-scale spatiotemporal patterns reflected additional lexical and syntactic features of speech. Morphological processing of the critical sound as verb inflection led to particularly pronounced early left-inferior-frontal activation, whereas the same sound functioning as inflectional affix of a noun activated superior-temporal cortex more strongly. We conclude that precisely timed spatiotemporal patterns involving specific cortical areas may represent a brain code of memory circuit activation. These spatiotemporal patterns are best explained in terms of synfire mechanisms linking neuronal populations in different cortical areas. The large-scale synfire chains appear to reflect the processing of stimuli together with the context-dependent perceptual and cognitive information bound to them.

Conference: MMN 09 Fifth Conference on Mismatch Negativity (MMN) and its Clinical and Scientific Applications, Budapest, Hungary, 4 Apr - 7 Apr, 2009.

Presentation Type: Poster Presentation

Topic: Poster Presentations

Citation: Shtyrov Y and Pulvermüller F (2009). Spatiotemporal Signatures Of Large-Scale Synfire Chains For Speech Processing As Revealed By MEG. Conference Abstract: MMN 09 Fifth Conference on Mismatch Negativity (MMN) and its Clinical and Scientific Applications. doi: 10.3389/conf.neuro.09.2009.05.055

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Received: 24 Mar 2009; Published Online: 24 Mar 2009.

* Correspondence: Yury Shtyrov, INSERM, Ecole Normale Superieure, Cambridge, United Kingdom, yury.shtyrov@cfin.au.dk

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