The role of serotonin and acetylcholine in mismatch negativity generation
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1
Department of Neuropsychology and Psychopharmacology, Maastricht University , Netherlands
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2
BioMag Laboratory, Helsinki University Central Hospital , Finland
Previous research has revealed that both cholinergic (ACh) and serotonergic (5-HT) manipulations not only affect mismatch negativity (MMN) amplitude, but may also be involved in novelty processing, as measured with P3a and P3b components. It is not yet clear to which extent ACh interacts with 5-HT in this matter. In a series of experiments, we examined whether MMN and P3a would decrease after lowering either ACh or 5-HT, and furthermore, whether this impairment could be reversed by increasing the other neurotransmitter, the latter manipulation indicating a possible interaction between the two neurotransmitters. We used scopolamine and biperiden (decrease ACh levels), acute tryptophan depletion (decreases 5-HT), rivastigmine (increases ACh), citalopram (increases 5-HT), and placebo treatments. In each study, a novelty oddball task was presented, which consisted of frequent standard, infrequent frequency deviants and infrequent novelty deviants (stimulus duration 300 ms and inter-stimulus interval 700 ms). The results of these studies will be used to interpret the role of ACh and 5-HT in MMN and P3a generation.
Conference:
MMN 09
Fifth Conference on Mismatch Negativity (MMN) and its Clinical and Scientific Applications, Budapest, Hungary, 4 Apr - 7 Apr, 2009.
Presentation Type:
Oral Presentation
Topic:
Abstracts
Citation:
Sambeth
A,
Blokland
A,
Kähkönen
S and
Riedel
WJ
(2009). The role of serotonin and acetylcholine in mismatch negativity generation.
Conference Abstract:
MMN 09
Fifth Conference on Mismatch Negativity (MMN) and its Clinical and Scientific Applications.
doi: 10.3389/conf.neuro.09.2009.05.072
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Received:
24 Mar 2009;
Published Online:
24 Mar 2009.
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Correspondence:
Anke Sambeth, Department of Neuropsychology and Psychopharmacology, Maastricht University, 6200 MD Maastricht, Netherlands, anke.sambeth@psychology.unimaas.nl