MMN: emotional dimension of distractor task in a simple duration mismatch paradigm
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1
P.C Dr. Guislain, Neurolab, Belgium
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2
P.C. Zoete Nood Gods, Belgium
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3
UGent, dept. of Applied Mathematics, Biometrics and Process Control, Belgium
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4
UGent, dept. of Medicine, UZ, Belgium
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5
UGent, dept. of Electrical Energy, Systems and Automation, Belgium
The use of the Mismatch negativity (MMN) in clinical cognitive neuropsychiatry has been promoted by the fact that its execution is largely independent on the voluntary cooperation of the patient. In fact conscious awareness of the presence of deviancy in a set of acoustic stimuli activates other components such as P3a and especially N2b that in it can be confusing as the latter has a time window and morphology that overlaps with MMN. So it has been custom practice to turn away the patient’s attention from the deviant stimuli by offering a distraction such as reading a book or viewing a silent movie. However as we know that in higher order deviances the emotional dimension of the stimulus can influence the parameters of the MMN response and realizing that personality traits (Hansenne et al.) such as avoidance or BIS in Cloningers model also has clear impact on MMN amplitude, we wanted to find out if emotional elements of the distraction content could have any influence on the amplitude or latency of the MMN response in a clinical low order acoustic stimulation paradigm. In a pilot study, 30 normal volunteers were tested in a duration deviant paradigm (Cecile Colin, et al.) while viewing 5 silent movies (each test lasted 5 minutes) whose theme was selected from the quadrants of valence and arousal taken from the IAPS database. Each participant rated the 5 movies on visual manikin scale from 0-9 for arousal and valence. Using standard data analysis tools such as correlation analysis, PCA and LDA and advanced data mining algorithms like support vector machines, no connection between MMN parameters and emotional dimensionality of the distraction task was found. A net influence of gender was withheld with women scoring higher amplitude MMN.
CONCLUSION: The relative insensitivity or “immunity” of the main MMN parameters in the simple duration deviance paradigm, in relation to the emotional dimensionality of the distracter task enhances the robustness of this test in the clinical theater as it lowers some of the biological variance for establishing its normal values. Further testing should now involve patients with well defined conditions such as schizophrenics, anxiety, OCD, depression, autism, addiction and some well defined personality phenotypes.
Conference:
MMN 09
Fifth Conference on Mismatch Negativity (MMN) and its Clinical and Scientific Applications, Budapest, Hungary, 4 Apr - 7 Apr, 2009.
Presentation Type:
Poster Presentation
Topic:
Poster Presentations
Citation:
Otte
G,
De-Bruecker
G,
Waegeman
W,
Geerts
PJ and
Wyns
B
(2009). MMN: emotional dimension of distractor task in a simple duration mismatch paradigm.
Conference Abstract:
MMN 09
Fifth Conference on Mismatch Negativity (MMN) and its Clinical and Scientific Applications.
doi: 10.3389/conf.neuro.09.2009.05.075
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Received:
30 Mar 2009;
Published Online:
30 Mar 2009.
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Correspondence:
Georges Otte, P.C Dr. Guislain, Neurolab, 9000 Ghent, Belgium, georges.otte@pandora.be