3D mapping of synaptic connections within "in silico" microcircuits of full compartmental neurons in extended networks on the example of VPM axons projecting into S1 of rats.
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1
Max Planck Institute for Neurobiology, Group Cortical Column in silico, Germany
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2
Zuse Institute Berlin, Germany
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3
IWR, Germany
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4
MPI for Medical Research, Germany
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5
MPI of Neurobiology, Germany
Determination of the number and 3D distribution of synaptic connections for individual neuron populations is a key prerequisite to establish large full compartmental neuron network models. Recently described methods for determination of synaptic contact sites using channelrhodopsin-2 (ChR2) (Petreanu et al., 2009) or serial block-face scanning electron microscopy (SBFSEM) (Seung & Denk, Connectomics Project) are promising but not yet satisfying in mapping all synaptic connections for large functional units such as a cortical column. In contrast to these "direct" methods, the statistical approach described here focuses on mapping synaptic connections onto anatomically determined microcircuits in average neuronal networks. A "toolbox" will be described on the example of thalamocortical synapses from neurons originating in the ventral posterior medial (VPM) thalamic nucleus and projecting into the primary somatosensory cortex (S1) of rats.
Conference:
Neuroinformatics 2009, Pilsen, Czechia, 6 Sep - 8 Sep, 2009.
Presentation Type:
Poster Presentation
Topic:
Computational neuroscience
Citation:
Oberlaender
M,
Dercksen
VJ,
Lang
S,
Helmstaedter
M and
Sakmann
B
(2019). 3D mapping of synaptic connections within "in silico" microcircuits of full compartmental neurons in extended networks on the example of VPM axons projecting into S1 of rats..
Front. Neuroinform.
Conference Abstract:
Neuroinformatics 2009.
doi: 10.3389/conf.neuro.11.2009.08.092
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Received:
22 May 2009;
Published Online:
09 May 2019.
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Correspondence:
Marcel Oberlaender, Max Planck Institute for Neurobiology, Group Cortical Column in silico, Munich, Germany, oberlaender@neuro.mpg.de