Complex fluctuations in neuronal oscillations: From a qualitative hallmark to disease-sensitive quantitative traits
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1
VU University Amsterdam, Department of Integrative Neurophysiology, Center for Neurogenomics and Cognitive Research (CNCR), Netherlands
Human brain oscillations fluctuate erratically in amplitude during rest and exhibit power-law decay of temporal correlations (Linkenkaer-Hansen et al., 2001). Recent progress in studying genetic (Linkenkaer-Hansen et al., 2007) and disease influences (Montez et al., 2009) of the complex temporal structure of ongoing oscillations, suggests that much information can be derived from time series analysis of ongoing activity, which is not detected with classical spectral methods. Some of the methods used to study the temporal structure are inspired by the statistical behavior of self-organizing complex systems near a critical state (Poil et al., 2008). In this talk, I will provide an introduction to the theoretical framework of critical dynamics in the context of spontaneous neuronal oscillations and give examples of how the quantitative tools developed on the back of this framework have helped us identify novel aspects of brain function in health and disease.
References
1. Linkenkaer-Hansen K, Nikouline VV, Palva JM, Ilmoniemi RJ (2001) Long-Range Temporal Correlations and Scaling Behavior in Human Brain Oscillations. J Neurosci 21:1370-1377.
2. Linkenkaer-Hansen K, Smit DJA, Barkil A, van Beijsterveldt TEM, Brussaard AB, Boomsma DI, van Ooyen A, de Geus EJC (2007) Genetic Contributions to Long-Range Temporal Correlations in Ongoing Oscillations. J Neurosci 27:13882-13889.
3. Montez T, Poil S-S, Jones BF, Manshanden I, Verbunt JPA, van Dijk BW, Brussaard AB, van Ooyen A, Stam CJ, Scheltens P, Linkenkaer-Hansen K (2009) Altered temporal correlations in parietal alpha and prefrontal theta oscillations in early-stage Alzheimer disease. Proceedings of the National Academy of Sciences 106:1614-1619.
4. Poil S-S, van Ooyen A, Linkenkaer-Hansen K (2008) Avalanche dynamics of human brain oscillations: Relation to critical branching processes and temporal correlations. Human Brain Mapping 29:770-777.
Conference:
Neuroinformatics 2009, Pilsen, Czechia, 6 Sep - 8 Sep, 2009.
Presentation Type:
Oral Presentation
Topic:
Workshop 1- Advances in the automatic analysis of multi-dimensional data
Citation:
Linkenkaer-Hansen
K
(2019). Complex fluctuations in neuronal oscillations: From a qualitative hallmark to disease-sensitive quantitative traits.
Front. Neuroinform.
Conference Abstract:
Neuroinformatics 2009.
doi: 10.3389/conf.neuro.11.2009.08.130
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Received:
10 Jun 2009;
Published Online:
09 May 2019.
*
Correspondence:
Klaus Linkenkaer-Hansen, VU University Amsterdam, Department of Integrative Neurophysiology, Center for Neurogenomics and Cognitive Research (CNCR), Cairo, Netherlands, klaus.linkenkaer@cncr.vu.nl