Porous scaffolds of poly (3-hydroxybutyrate) fabricated by Selective Laser Sintering technology (SLS) for bone engineering
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1
Federal University of Rio de Janeiro, Metallurgical and Materials Engineering, Brazil
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2
Center for Information Technology Renato Archer, Division of 3D Technologies, Brazil
In this study, Selective Laser Sintering Technology (SLS) was used for the construction of porous scaffolds of poly (3-hydroxybutyrate) with potential application in bone engineering. The influence of the SLS process parameters on morphological and mechanical properties of the scaffolds made from two different digital models was evaluated. The results indicated the possibility of reuse of the remaining SLS processing powder. The first model was reproduced using different laser power (PL), resulting scaffolds with porosity ranging from 51.6 to 77.5% and mechanical properties with anisotropic characteristics in compression. The second model was built following 33 complete factorial design, and the optimal parameters laser power (18.8 W), the scan spacing (0.19 mm) and layer thickness (0.13 mm) were determined to obtain scaffolds having the following approximate characteristics: a low to moderate distortion in the structure, dimensional deviation from the computational model 43% (pore size) and 2.37% (external dimensions), degree of porosity of 70%, modulus and compression strength of 35 MPa and 1.5 MPa, respectively.
Our special thanks to the brazilians agencies CNPq, FAPERJ, FAPESP (2008/57860-3) and PROCAD/CAPES.
References:
[1] Alessandro Franco, Luca Romoli. Characterization of laser energy consumption in sintering of polymer based powders. Journal of Materials Processing Technology. Volume 212, Issue 4, Pages 735-988 (April 2012).
[2] Dietmar Hutmacher. Scaffolds in tissue engineering bone and cartilage. Biomaterials. Volume 21, Issue 24, 15 December 2000, Pages 2529–2543
[3] Nguyen, S. and Marchessault, R. H. (2004), Synthesis and Properties of Graft Copolymers Based on Poly(3-hydroxybutyrate) Macromonomers. Macromol. Biosci., 4: 262–268. doi: 10.1002/mabi.200300088
[4] Y Shi, Z Li, H Sun, S Huang, F Zeng. Effect of the properties of the polymer materials on the quality of selective laser sintering parts. Proceedings of the Institution of Mechanical Engineers, Part L: Journal of Materials: Design and ApplicationsJuly 1, 2004 vol. 218 no. 3 247-252
Keywords:
biomaterial,
polymer,
Rapid prototyping,
3D scaffold
Conference:
10th World Biomaterials Congress, Montréal, Canada, 17 May - 22 May, 2016.
Presentation Type:
Poster
Topic:
Biomaterials in constructing tissue substitutes
Citation:
Pereira
TF,
Oliveira
MF,
Maia
IA,
Rezende
R,
Costa
MF,
Thiré
RM and
Da Silva
JL
(2016). Porous scaffolds of poly (3-hydroxybutyrate) fabricated by Selective Laser Sintering technology (SLS) for bone engineering.
Front. Bioeng. Biotechnol.
Conference Abstract:
10th World Biomaterials Congress.
doi: 10.3389/conf.FBIOE.2016.01.00248
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Received:
28 Mar 2016;
Published Online:
30 Mar 2016.