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Study on the rapamycin release from a PLGA layer on biodegradable Mg-based drug-eluting stents

Guangyin Yuan1, Yongjuan Shi1 and Jia Pei1
  • 1 Shanghai Jiao Tong University, School of Materials Science & Engineering, China

A magnesium-based alloy (Mg alloy), which is known to be biodegradable and biocompatible, has been considered as a potential material for the next-generation drug-eluting stents (DESs)[1],[2]. In this study, the interactions among Mg-Nd-Zn-Zr alloy, rapamycin and drug carrier PLGA were studied. The effect of a rapamycin- containing poly(lactic-co-glycolic acid) (PLGA) layer on the degradation properties of Mg alloy was examined. Mg can react with water to produce Mg2+, hydrogen (H2) and OH-.  An in vitro hydrogen evolution test showed that a PLGA coating provided short-term protection of the Mg alloy substrate and reduced its degradation rate. The degradation of the Mg alloy deteriorated the stability of rapamycin, as the increased pH accelerated hydrolysis of rapamycin. In vitro drug release in phosphate buffered saline with 0.5% Tween 20 (PBST) showed that degradation of Mg alloy accelerated the rate of drug release from the PLGA layer, as compared with that ofthe PLGA layer on a stainless steel substrate. Our study collectively suggests that hydrogen produced from Mg alloy degradation played a significant role in the accelerated rapamycin release, while the effect of pH increase of the release medium was unobvious.

This work was supported by the Science and Technology Commission of Shanghai Municipality (No. 14DZ1940800) ,China

References:
[1] M. Haude, R. Erbel, P. Erne, S. Verheye, H. Degen, D. Böse, P. Vermeersch, I. Wijnbergen, N. Weissman, F. Prati, R. Waksman, J. Koolen, Safety and performance of the drug-eluting absorbable metal scaffold (DREAMS) in patients with de-novo coronary lesions: 12 month results of the prospective, multicentre, first-in-man BIOSOLVE-I trial, The Lancet. 381(2013) 836-844.
[2] M. Haude, R. Erbel, P. Erne, S. Verheye, P. Vermeersch, H. Degen, D. Böse, R. Waksman, N.J. Weissmann, F. Prati, J. Koolen, CRT-715 Long Term Clinical Data Of The BIOSOLVE-I Study With The Paclitaxel-eluting Absorbable Magnesium Scaffold (DREAMS) And Multi-modality Imaging Analysis, JACC: Cardiovascular Interventions. 8(2015) S2-S3.

Keywords: drug, corrosion, Surface modification, Biodegradable metal

Conference: 10th World Biomaterials Congress, Montréal, Canada, 17 May - 22 May, 2016.

Presentation Type: Poster

Topic: Biomaterials for cardiovascular applications, vascular grafts and embolic devices

Citation: Yuan G, Shi Y and Pei J (2016). Study on the rapamycin release from a PLGA layer on biodegradable Mg-based drug-eluting stents. Front. Bioeng. Biotechnol. Conference Abstract: 10th World Biomaterials Congress. doi: 10.3389/conf.FBIOE.2016.01.01218

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Received: 27 Mar 2016; Published Online: 30 Mar 2016.