Event Abstract

Back to Event

Choline phosphate functionalized cellulose membrane developed as potential hemostasis dressing based on a unique bioadhesion mechanism

Xiaoqiang Yang1, Jayachandran Kizhakkedathu1* and Donald Brooks1*
  • 1 Life Science Institution, Department of Pathology, Canada

A choline phosphate functionalized biocompatible cellulose membrane that can efficiently arrest human red blood cells was developed to have potential application in wound dressing. The bioadhesion is based on the unique multivalent electrostatic interaction between the head groups of phosphatidyl choline based lipids on the cell membrane and its inverse orientation but virtually identical structure, choline phosphate, coupled to the cellulose membrane. For functionalization, the cellulose membrane was decorated with the polymer brushes bearing multiple choline phosphate groups via surface-initiator atom transfer radical polymerization followed by the click chemistry. The molecular weight and the grafting density of polymer brushes grafted from the cellulose membrane surface were thoroughly evaluated by force-distance measurements using atomic force microscopy. The dependence on the number density of choline phosphate groups and the grafting density of human red blood cell binding to the cellulose membrane surface is reported.

Keywords: Cell Adhesion, biomaterial, Biocompatibility

Conference: 10th World Biomaterials Congress, Montréal, Canada, 17 May - 22 May, 2016.

Presentation Type: General Session Oral

Topic: Adhesive biomaterials

Citation: Yang X, Kizhakkedathu J and Brooks D (2016). Choline phosphate functionalized cellulose membrane developed as potential hemostasis dressing based on a unique bioadhesion mechanism. Front. Bioeng. Biotechnol. Conference Abstract: 10th World Biomaterials Congress. doi: 10.3389/conf.FBIOE.2016.01.01220

Copyright: The abstracts in this collection have not been subject to any Frontiers peer review or checks, and are not endorsed by Frontiers. They are made available through the Frontiers publishing platform as a service to conference organizers and presenters.

The copyright in the individual abstracts is owned by the author of each abstract or his/her employer unless otherwise stated.

Each abstract, as well as the collection of abstracts, are published under a Creative Commons CC-BY 4.0 (attribution) licence (https://creativecommons.org/licenses/by/4.0/) and may thus be reproduced, translated, adapted and be the subject of derivative works provided the authors and Frontiers are attributed.

For Frontiers’ terms and conditions please see https://www.frontiersin.org/legal/terms-and-conditions.

Received: 27 Mar 2016; Published Online: 30 Mar 2016.

* Correspondence:
Dr. Jayachandran Kizhakkedathu, Life Science Institution, Department of Pathology, Vancouver, BC, Canada, jay@pathology.ubc.ca
Dr. Donald Brooks, Life Science Institution, Department of Pathology, Vancouver, BC, Canada, don.brooks@ubc.ca