Information flow between subthalamic nucleus and cortex in error processing and the influence of dopaminergic treatment
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1
Department of Neurology, Charité, Germany
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2
Department of Neurosurgery, Charité - University Medicine Berlin, Germany
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3
Donders Institute for Brain, Cognition and Behaviour, Netherlands
Error processing (EP) is crucial for optimizing motor behaviour. Midbrain dopaminergic (DA) neurons are suggested to convey error-related signals to the basal ganglia and posterior fronto-medial cortex (pFMC). The aim of our study was to investigate the role of the subthalamic nucleus (STN) in EP. Local field potentials (LFPs) from the STN and scalp EEG (FCz, Cz) were recorded during a flanker task in 16 Parkinson’s disease (PD) patients ON and OFF levodopa undergoing deep brain stimulation. We performed event-related potential (ERP) analysis of LFP and EEG signals time-locked to incongruent responses. By means of the partial directed coherence (PDC) we assessed directional influences between oscillatory activity in STN (LFP) and pFMC (EEG) during EP. We found a significant error-related negativity and error positivity in EEG (p < .05). In STN-LFP the ERP at response onset was larger for the correct responses compared to erroneous trials. An error-related deflection occurred at 150-400 ms (p < .05). In patients with a higher error rate (ER) ON medication as compared to OFF (n = 8, p < .008), the late STN-ERP component was more robust in OFF (p < .006). PDC analysis revealed a bidirectional influence mediated by beta (15-30 Hz) and gamma oscillations (60-80 Hz) for errors, which was significantly more prominent from STN to cortex (250-450 ms) in OFF in PD with lower ER in OFF. We found STN involvement in late EP and error-related bidirectional flow between STN and pFMC. Patients with higher ER ON medication showed a robust STN-ERP and a pronounced influence from STN to pFMC only off medication thus suggesting possibly impaired learning from errors under DA treatment, similar to the impaired negative learning suggested by Frank et al. (2004).
Keywords:
decision-making,
EEG
Conference:
XI International Conference on Cognitive Neuroscience (ICON XI), Palma, Mallorca, Spain, 25 Sep - 29 Sep, 2011.
Presentation Type:
Poster Presentation
Topic:
Poster Sessions: Decision Making, Reward Processing & Response Selection
Citation:
Siegert
S,
Herrojo Ruiz
M,
Huebl
J,
Brücke
C,
Schneider
G,
Schoenecker
T,
Ullsperger
M and
Kühn
AA
(2011). Information flow between subthalamic nucleus and cortex in error processing and the influence of dopaminergic treatment.
Conference Abstract:
XI International Conference on Cognitive Neuroscience (ICON XI).
doi: 10.3389/conf.fnhum.2011.207.00376
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Received:
23 Nov 2011;
Published Online:
28 Nov 2011.
*
Correspondence:
Dr. Sandy Siegert, Department of Neurology, Charité, Berlin, Germany, sandy.siegert@charite.de