Event Abstract

Back to Event

Negative biases and the slow negative wave in Parkinson's disease

Tiffany Au1, Anthony Angwin2, David Copland2, 3, John O'Sullivan4, Gerard Byrne5, 6, Peter Silburn2, 3, Rodney Marsh5, 6, George Mellick2, 7 and Nadeeka Dissanayaka3, 8*
  • 1 The University of Queensland Centre for Clinical Research, UQ Centre for Clinical Research, Australia
  • 2 The University of Queensland, School of Health & Rehabilitation Sciences, Australia
  • 3 The University of Queensland, UQ Centre for Clinical Research, Australia
  • 4 Royal Brisbane & Women's Hospital, Neurology Research Centre, Australia
  • 5 The University of Queensland, School of Medicine, Australia
  • 6 Royal Brisbane & Women's Hospital, Department of Psychiatry, Australia
  • 7 Griffith University , Eskitis Institute for Cell & Molecular Therapies, Australia
  • 8 Royal Brisbane & Women's Hospital, Neurology Reserch Centre, Australia

Background: Negative compared to neutral stimuli are more likely to gain attention, and show larger event related potentials (ERPs). In Parkinson’s disease (PD), blunted emotional responses are observed. A loss of the slow negative wave (SNW) that is associated with pre-processing of motor response has also been reported in PD, yet its influence on judgements towards emotional responses is unclear. This study investigates how PD alters ERPs associated with negative biases, and influences the SNW when a response is executed for negative compared to neutral stimuli. Methods: Twenty two (22) non-demented PD patients without affective disturbances and 17 controls completed a visual word affective priming task while ERPs were recorded. The paradigm consisted of presenting negatively or neutrally valanced word pairs (both congruent and incongruent) with a stimulus onset asynchrony of 250ms. The target word valence was evaluated via button press. Amplitudes of ERP components were examined using repeated measures ANOVA (factors of Group, congruency, and target valence). Results: P3 and LPP amplitudes were larger for negative compared to neutral target valences at Pz electrode. While there were no Group X Target valence interactions (P3 F=0.16; p=0.69, LPP F=0.03, p=0.86), a significant overall target valence effect was observed (P3 F=13.72, p<0.01, LPP F=12.86, p<0.01). A Group X Target valence interaction was observed for the SNW at left central electrode cluster (F=6.33, p=0.02). The SNW was larger for negative compared to neutral targets for controls (F=7.32; p=0.02). The PD group showed no significant difference between the SNW amplitude of negative compared to neutral targets (F=0.14; p=0.72). Conclusion: P3 and LPP indicating negative biases are intact in PD. The SNW for negative compared to neutral stimuli show a larger amplitude deflection in healthy older adults, but not PD. Pre-processing of motor responses for negative stimuli is altered in PD.

Keywords: Parkinson's disease, Event Related Potentials, LPP, P3, lateralised readiness potential, negative biases

Conference: XII International Conference on Cognitive Neuroscience (ICON-XII), Brisbane, Queensland, Australia, 27 Jul - 31 Jul, 2014.

Presentation Type: Poster

Topic: Emotional and Social Processes

Citation: Au T, Angwin A, Copland D, O'Sullivan J, Byrne G, Silburn P, Marsh R, Mellick G and Dissanayaka N (2015). Negative biases and the slow negative wave in Parkinson's disease. Conference Abstract: XII International Conference on Cognitive Neuroscience (ICON-XII). doi: 10.3389/conf.fnhum.2015.217.00074

Copyright: The abstracts in this collection have not been subject to any Frontiers peer review or checks, and are not endorsed by Frontiers. They are made available through the Frontiers publishing platform as a service to conference organizers and presenters.

The copyright in the individual abstracts is owned by the author of each abstract or his/her employer unless otherwise stated.

Each abstract, as well as the collection of abstracts, are published under a Creative Commons CC-BY 4.0 (attribution) licence (https://creativecommons.org/licenses/by/4.0/) and may thus be reproduced, translated, adapted and be the subject of derivative works provided the authors and Frontiers are attributed.

For Frontiers’ terms and conditions please see https://www.frontiersin.org/legal/terms-and-conditions.

Received: 19 Feb 2015; Published Online: 24 Apr 2015.

* Correspondence: Dr. Nadeeka Dissanayaka, The University of Queensland, UQ Centre for Clinical Research, Brisbane, Australia, n.dissanayaka@uq.edu.au