Ongoing spontaneous activity dynamics in zebrafish larvae
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1
Ecole Normale Superieure, Section of Neurosciences, France
In a state of sensory deprivation, sensory areas in the brain remain
highly active. This activity, once interpreted as irrelevant noise, has
been found to exhibit highly coherent spatiotemporal structures.
To understand the biological meaning of these ongoing activities we are
using the zebrafish larva as the experimental model which enable
monitoring the activity of large portions of the nervous system with
single-cell resolution in an intact behaving vertebrate, while presenting
visual natural stimuli.
Our preliminary data suggest that the ongoing spontaneous tectal activity
shows a biological relevant structure where retinotopic rather than
directional selective ensembles may represent local circuit attractors
that can increase the signal-to-noise ratio for stimulus detection in
low-contrast or cluttering backgrounds.
Acknowledgements
ERC stg, ERASysBio+
Keywords:
two-photon calcium imaging,
ongoing brain activity,
Zebrafish,
network dynamics,
motor behaviour
Conference:
Tenth International Congress of Neuroethology, College Park. Maryland USA, United States, 5 Aug - 10 Aug, 2012.
Presentation Type:
Invited Symposium (only for people who have been invited to a particular symposium)
Topic:
Novel Tools and Methods
Citation:
Sumbre
G
(2012). Ongoing spontaneous activity dynamics in zebrafish larvae.
Conference Abstract:
Tenth International Congress of Neuroethology.
doi: 10.3389/conf.fnbeh.2012.27.00065
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Received:
04 Jul 2012;
Published Online:
07 Jul 2012.
*
Correspondence:
Dr. German Sumbre, Ecole Normale Superieure, Section of Neurosciences, Paris, France, sumbre@biologie.ens.fr