Tic-related neuronal activity in the cortico-basal ganglia loop
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1
Bar Ilan University, Gonda Brain Research Center, Israel
Motor tics are brief, repetitive, involuntary muscle contractions that interfere with ongoing behavior and are a symptom of several neural disorders, most notably Tourette syndrome. While the pathophysiology of tics is still largely unknown, multiple lines of evidence suggest the involvement of the cortico-basal ganglia loop in tic disorders, specifically the striatum. Theoretical models hypothesized an abnormal "action selection" process leading to tic generation in which an aberrant focus of striatal activation causes unwanted inhibition of a group of basal ganglia output neurons, which, in turn, disinhibit a group of cortical neurons and thus leads to the expression of a tic. We transiently induced motor tics in freely behaving monkeys and rats by local microinjections of GABAA antagonists into the striatum. Multi-electrode recordings following the injection reveal tic related activity throughout the cortico-basal ganglia loop. We characterized the temporal and spatial distribution of tic-related activity in each area and their relation to the spatial and temporal properties of the tic manifestation. Our results indicate that rather than selecting and initiating the abnormal movement the tic-related basal ganglia signal may have a more complex role in the modulation and control of tics.
Acknowledgements
This work was supported by Israel Science Foundation (ISF) grant 327/09 and a Tourette Syndrome Association (TSA) grant.
Keywords:
Basal Ganglia,
Striatum,
Bicuculline,
Primates,
Tic Disorders,
Tourette Syndrome,
extracellular recordings,
multielectrode recordings
Conference:
4th Conference of the Mediterrarnean Neuroscience Society, Istanbul, Türkiye, 30 Sep - 3 Oct, 2012.
Presentation Type:
Symposium
Topic:
Abstracts
Citation:
Bronfeld
M,
Israelashvili
M and
Bar‐Gad
I
(2013). Tic-related neuronal activity in the cortico-basal ganglia loop.
Conference Abstract:
4th Conference of the Mediterrarnean Neuroscience Society.
doi: 10.3389/conf.fnhum.2013.210.00011
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Received:
27 Jan 2013;
Published Online:
11 Apr 2013.
*
Correspondence:
Dr. Izhar Bar‐Gad, Bar Ilan University, Gonda Brain Research Center, Ramat Gan, 52900, Israel, bargadi@mail.biu.ac.il