Osmoregulation, vasopressin expression and free radicals.
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1
Univeristy Pierre and Marie Curie - Paris 6, Physiopathologie des Maladies du Systeme Nerveux Central, France
Fluid restriction consitutes a stressful situation that animals have to face. The hypothalamic-neurohypophysial system is responsible for the expression and release of vasopressin which induces renal reabsorption of water, thus ensuring the balance of plasma osmolality.
Our team focused on cellular and molecular mechanisms that regulate vasopressin expression and, particularly on the role of noradrenergic afferents connecting the neuroendocrine hypothalamus. The participation of several actors was exhibited in these complex cellular interactions: nitric oxide, astrocytes, extracellular matrix ... Recently, we demonstrated that free radicals are essential for the increased expression of vasopressin during osmotic stimulation, highlighting a new role of free radicals as physiological mediators.
References
St-Louis R, Parmentier C, Raison D, Grange-Messent V, Hardin-Pouzet H. Reactive oxygen species are required for the hypothalamic osmoregulatory response. Endocrinology. 2012 Mar;153(3):1317-29. doi: 10.1210/en.2011-1350.
Keywords:
vasopressin,
Free Radicals,
Hypothalamus,
Supraoptic Nucleus,
noradrenaline
Conference:
4th Conference of the Mediterrarnean Neuroscience Society, Istanbul, Türkiye, 30 Sep - 3 Oct, 2012.
Presentation Type:
Symposium
Topic:
Abstracts
Citation:
HARDIN-POUZET
H
(2013). Osmoregulation, vasopressin expression and free radicals..
Conference Abstract:
4th Conference of the Mediterrarnean Neuroscience Society.
doi: 10.3389/conf.fnhum.2013.210.00037
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Received:
28 Jan 2013;
Published Online:
11 Apr 2013.
*
Correspondence:
Prof. Helene HARDIN-POUZET, Univeristy Pierre and Marie Curie - Paris 6, Physiopathologie des Maladies du Systeme Nerveux Central, Paris, 75005, France, helene.pouzet@snv.jussieu.fr