Functional Mapping of the Bladder Regulatory System: Communication between the Lower Urinary Tract and the Central Nervous System
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1
Faculty of Health Medicine and Life Sciences, Maastricht University, Department of Neuroscience, Netherlands
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2
Faculty of Health Medicine and Life Sciences, Maastricht University, Department of Neuroscience, Netherlands
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3
European Graduate School of Neuroscience, Netherlands
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4
Faculty of Health Medicine and Life Sciences, Maastricht University, Department of Neuroscience, Netherlands
The literature on urinary symptoms describes an incidence about 16 % among people over 50 years that increases with age. In this context, it is necessary to understand the physiological and pathological processes involved in the micturition and the urinary continence for the development of new and more specific treatment options.
One of the most frequently encountered urological disorders is the overactive bladder symptom complex. According to knowledge on the bladder innervation, several hypotheses have been proposed to explain the origins of the increased activity of the detrusor muscle.
Indeed the functions of the lower urinary tract are controlled by complex pathways in the central nervous system as the periaqueductal gray (PAG) or the pontine micturition center (PMC) that act like switching circuits to voluntarily or reflexly shift the activity of various pelvic organs (bladder, urethra, …) from urine storage to voiding. Therefore incontinence could be related to the deregulation of these efferent or afferent pathways.
The juxtacellular recording-labeling technique is a powerful tool achieving single-cell structure/function correlation studies in living animal. This non-invasive single-cell filling procedure allows to keep alive the extracellularly recorded and stimulated neuron and so to reveal the overall picture of the smallest neurons, including interneurons and to investigate the physiological and architectural bases of cell-cell communication.
In order to evaluate the effect of the increased pressure in the urinary bladder on the neural activity, the in vivo cystometry technique will be performed at the same time.
Taking into account that the rodents bladder shows several features similar to those reported in humans, the experiments will be undertaken in rat.
In this project, the juxtacellular recording - labeling technique in combination with in vivo cystometry in rat will be used to map the neural innervation in the PAG and to understand the sensory perception and the processing during bladder filling.
Acknowledgements
This work is supported by Curie Actions (European Project)
Keywords:
Periaqueductal gray matter,
bladder afferent activity,
in vivo electrophysiology,
Urodynamics,
Rats, Sprague-Dawley
Conference:
4th Conference of the Mediterrarnean Neuroscience Society, Istanbul, Türkiye, 30 Sep - 3 Oct, 2012.
Presentation Type:
Poster Presentation
Topic:
Abstracts
Citation:
Meriaux
C,
Van Koeveringe
G,
Temel
Y and
Steinbusch
HW
(2013). Functional Mapping of the Bladder Regulatory System: Communication between the Lower Urinary Tract and the Central Nervous System.
Conference Abstract:
4th Conference of the Mediterrarnean Neuroscience Society.
doi: 10.3389/conf.fnhum.2013.210.00049
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Received:
25 Jan 2013;
Published Online:
11 Apr 2013.
*
Correspondence:
Dr. Céline Meriaux, Faculty of Health Medicine and Life Sciences, Maastricht University, Department of Neuroscience, Maastricht, 6200 MD, Netherlands, celine.meriaux@inserm.fr