Brain functional connectivity, dopamine and the default mode network in ADHD
-
1
Swinburne University of Technology, Australia
-
2
Neuro-Insight Pty Ltd, Australia
Recent evidence suggests that Attention Deficit Hyperactivity Disorder (ADHD) is associated with reduced inhibition of the default mode network (DMN) while performing a cognitive task. In this study, we use steady state visual evoked potential event related partial coherence as a measure of brain functional connectivity to examine functional connectivity differences between a control group of 25 boys and an age/IQ matched group of 42 boys newly diagnosed with ADHD. Functional connectivity was estimated while both groups performed a low demand reference task and the A-X version of the continuous performance task (CPT A-X). Functional connectivity estimates were repeated in the ADHD group 90 minutes after the administration of the first dose of methylphenidate (Ritalin). Controls exhibited high parieto-frontal connectivity during specific components of the reference task and this was supressed during the equivalent point in time in the more demanding CPT A-X task. By contrast, the pre-methylphenidate ADHD group exhibited a robust increase in parieto-frontal functional connectivity during the CPT A-X task. The administration of methylphenidate reversed the increase in parieto-frontal connectivity and appeared to normalize the pattern of functional connectivity in the ADHD group. These findings will be discussed in the context of the possible role of the DMN in ADHD symptomatology.
Keywords:
ADHD,
Default Mode Network,
Dopamine,
brain functional connectivity,
Steady state evoked potentials
Conference:
ASP2015 - 25th Annual Conference of the Australasian Society for Psychophysiology, Sydney, Australia, 2 Dec - 4 Dec, 2015.
Presentation Type:
Oral Presentation
Topic:
Psychophysiology
Citation:
Silberstein
RB,
Pipingas
A,
Stough
C,
Camfield
DA and
Farrow
M
(2015). Brain functional connectivity, dopamine and the default mode network in ADHD.
Conference Abstract:
ASP2015 - 25th Annual Conference of the Australasian Society for Psychophysiology.
doi: 10.3389/conf.fnhum.2015.219.00046
Copyright:
The abstracts in this collection have not been subject to any Frontiers peer review or checks, and are not endorsed by Frontiers.
They are made available through the Frontiers publishing platform as a service to conference organizers and presenters.
The copyright in the individual abstracts is owned by the author of each abstract or his/her employer unless otherwise stated.
Each abstract, as well as the collection of abstracts, are published under a Creative Commons CC-BY 4.0 (attribution) licence (https://creativecommons.org/licenses/by/4.0/) and may thus be reproduced, translated, adapted and be the subject of derivative works provided the authors and Frontiers are attributed.
For Frontiers’ terms and conditions please see https://www.frontiersin.org/legal/terms-and-conditions.
Received:
21 Oct 2015;
Published Online:
30 Nov 2015.
*
Correspondence:
Prof. Richard B Silberstein, Swinburne University of Technology, Melbourne, Australia, rsilberstein@neuro-insight.com.au