Persistence of dysfunctional auditory information processing following pharmacotherapy in Internet gaming disorder: an event-related potential study
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1
Department of Psychiatry, SMG-SNU Boramae Medical Center, Republic of Korea
Aims: Internet gaming disorder (IGD), defined as inability to control internet-based games, leads to serious impairment in psychological and social functioning, but few studies exist that identify neurophysiological characteristics in IGD. The aim of this study was to determine neurophysiological markers associated with symptom changes in IGD patients following pharmacotherapy with outpatient management.
Methods: Eighteen patients diagnosed with IGD (22.61 ± 5.10 years), and 29 healthy controls (HCs; 24.66 ± 3.80 years) participated in this study. IGD patients completed a 6-month of serotonin reuptake inhibitors (SRIs)-based pharmacotherapy. Event-related potential (ERP) were acquired during an auditory oddball task in participants who were young adult males. For the IGD patients, ERP was recorded prior to and after treatment. Between-group differences and the pre-post treatment differences in P300 components were investigated using repeated measures analysis of variance. The primary treatment outcome was a change in score on the Young’s Internet Addiction Test from before and after treatment.
Results: The IGD group showed significantly reduced P300 amplitudes at midline centro-parietal site compared with those in HC. Reduced P300 amplitudes in the IGD were not correlated with scores on Internet Addiction severity. After 6 months of treatment, there were no significant changes in P300 amplitudes between pre- and post-treatment of IGD, even though, the IGD patients exhibited significant improvements of their IGD symptoms measured by Young’s Internet Addiction Test. Furthermore, there were no significant ERP differences between responder and non-responder to a 6-month pharmacotherapy in patients with IGD.
Conclusion: These results indicate that IGD has abnormalities of P300 index and reduced P300 amplitudes could be considered as a candidate trait marker of IGD. This study enhances our understanding of neurophysiological characteristics of IGD.
Acknowledgements
This work was supported by a grant from the National Research Foundation of Korea (2014M3C7A1062894).
Keywords:
event-related potential (ERP),
Internet Gaming Disorder (IGD),
Pharmacotherapy,
Serotonin reuptake inhibitors,
auditory information processing
Conference:
ASP2016 - The 26th Annual Meeting of the Australasian Society for Psychophysiology, Adelaide Australia, Adelaide,SA, Australia, 12 Dec - 14 Dec, 2016.
Presentation Type:
Poster Presentation
Topic:
Abstract (general)
Citation:
Choi
J,
Park
M and
Kim
Y
(2016). Persistence of dysfunctional auditory information processing following pharmacotherapy in Internet gaming disorder: an event-related potential study.
Conference Abstract:
ASP2016 - The 26th Annual Meeting of the Australasian Society for Psychophysiology, Adelaide Australia.
doi: 10.3389/conf.fnhum.2016.221.00022
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Received:
29 Oct 2016;
Published Online:
05 Dec 2016.
*
Correspondence:
Prof. Jung-Seok Choi, Department of Psychiatry, SMG-SNU Boramae Medical Center, Seoul, Republic of Korea, choijs73@gmail.com