Event Abstract

The effect of KIBRA rs17070145 polymorphism on cortical arousal

  • 1 Western Sydney University, NICM, Australia
  • 2 University of Wollongong, Brain & Behaviour Research Institute and School of Psychology, Australia
  • 3 University of Wollongong, Illawarra Health and Medical Research Institute and Faculty of Science, Medicine and Health, Australia
  • 4 Schizophrenia Research Institute, Australia
  • 5 Australian Catholic University, School of Science, Australia
  • 6 Macquarie University, Faculty of Medicine and Health Sciences, Australia

Aims: KIBRA (KIdney/BRAin) is a postsynaptic scaffolding protein implicated in cell motility and polarity, learning and memory, and synaptic plasticity. A functional single nucleotide polymorphism (SNP) identified in the KIBRA gene (rs17070145, C/T substitution), that encodes the KIBRA protein, has been linked to improved episodic memory ability and reduced risk of Alzheimer’s disease (AD). The present study aimed to investigate the association between KIBRA T allele carrier status and EEG activity to highlight neurophysiological mechanisms underpinning AD risk. Methods: Resting eyes open EEG activity from 97 young adults (Mean age = 21.3, SD = 4.9 years) was continuously recorded from 30 scalp sites at 1000Hz for 4 minutes; all participants provided a saliva sample for DNA extraction and analysis. High-throughput MassARRAY® genotyping assay was used for identifying KIBRA genotypes. Mean EEG band amplitudes were analysed for delta, theta, alpha-1, alpha-2, beta-1, and beta-2. Results: Alpha-1 was significantly associated with the KIBRA T allele carrier (C/T and T/T): parietal amplitudes in the right hemisphere were larger for individuals who did not carry the T allele (non-carriers, C/C) than carriers. Midline delta, fronto-midline theta, parietal alpha-2, fronto-parietal beta-1, and frontal beta-2 were not associated with rs17070145 genotype. Conclusions: Results indicate that alpha-1 activity is associated with KIBRA T allele carrier status. Alpha activity is inversely correlated with arousal, which suggests that individuals carrying the KIBRA T allele have higher arousal than homozygous C allele carriers. This finding may support the implicated molecular role of KIBRA involving its binding to atypical protein kinase C zeta, leading to increased alpha-amino-3-hydroxyl-5-methyl-4-isoxazole-proprionate (AMPA) receptor turnover. Consequently, this upregulates glutamate and may explain the increased arousal observed in T allele carriers. Given the role of AMPA receptors in long-term potentiation, this finding may provide insight into a possible mechanism for reduced AD risk.

Keywords: Electroencephalography, KIBRA, single nucleotide polymorphism (SNP), Alzheimer's disease, Memory

Conference: ASP2017: 27th Annual Meeting for the Australasian Society for Psychophysiology, Parramatta, Australia, 29 Nov - 1 Dec, 2017.

Presentation Type: Oral Presentation

Topic: Abstract (Student Award)

Citation: Al-Dabbas MA, Steiner GZ, Fernandez FM, Narula RS, Barkus E, Broyd SJ, Solowij N, Chiu C, Lind J and Barry RJ (2019). The effect of KIBRA rs17070145 polymorphism on cortical arousal. Conference Abstract: ASP2017: 27th Annual Meeting for the Australasian Society for Psychophysiology. doi: 10.3389/conf.fnhum.2017.224.00016

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Received: 30 Oct 2017; Published Online: 25 Jan 2019.

* Correspondence: Mr. Mahmoud A Al-Dabbas, Western Sydney University, NICM, Penrith, NSW, 2751, Australia, mah.aldabbas@gmail.com