Relating extrinsic connections to the intrinsic architecture of the cerebral cortex
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1
University Medical Center Hamburg-Eppendorf, Department of Computational Neuroscience, Germany
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2
Boston University, Department of Health Sciences, United States
The nerve fibre projections that connect different areas of the cortical sheet constitute a complex structural network for neural communication in the brain. How is the organization of this cortical connectome related to other features of brain architecture? We addressed the question by systematically investigating the relation of structural parameters of cortical areas, such as their distance, similarity in cortical cytoarchitecture as described by cortical lamination or neuronal density, as well as similarity of cortical thickness, to essential features of long-range cortico-cortical connections, such as their presence or absence as well as patterns of laminar projection origins and terminations.
Across different species (primate, cat, mouse) and different cortical lobes, the essential features of cortico-cortical connections varied consistently and strongly with the cytoarchitectonic similarity of cortical areas. By contrast, such relations were not found consistently for distance or similarity of cortical thickness. As gradients in cortical cytoarchitecture also determine the specific organisation of the local micro-circuits of different areas, our findings illuminate general principles of neural wiring, linking the organization of long-range connections to intrinsic circuits of the cerebral cortex.
Keywords:
connectomes,
Cerebral Cortex,
Cytoarchitecture,
connectivity,
human brain,
monkey,
Cats,
Mouse
Conference:
Neuroinformatics 2016, Reading, United Kingdom, 3 Sep - 4 Sep, 2016.
Presentation Type:
Investigator presentations
Topic:
General neuroinformatics
Citation:
Hilgetag
CC
(2016). Relating extrinsic connections to the intrinsic architecture of the cerebral cortex.
Front. Neuroinform.
Conference Abstract:
Neuroinformatics 2016.
doi: 10.3389/conf.fninf.2016.20.00017
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Received:
27 Apr 2016;
Published Online:
18 Jul 2016.
*
Correspondence:
Dr. Claus C Hilgetag, University Medical Center Hamburg-Eppendorf, Department of Computational Neuroscience, Hamburg, D-20246, Germany, c.hilgetag@gmail.com