Periodontal disease and its relationship with ultrasensitive C-Reactive Protein (hsC-RP): a prospective, randomized, cross-sectional, case-control study in subjects with type 2 diabetes.
-
1
University of Valencia, Department of Stomatology, Spain
-
2
University of Milano-Bicocca, Department of Medicine and Surgery, Italy
-
3
Department of Psychology, University of Campania 'Luigi Vanvitelli, Multidisciplinary Department of Medical-Surgical and Dental Specialties, Italy
-
4
University of Ferrara, Department of Morphology, Experimental Medicine and Surgery, Italy
Aim. The aim of this research is to study the periodontal status of patients with type 2 diabetes mellitus, verifying its impact on systemic inflammation.
Materials and Methods. A total of 93 individuals were studied, 47 patients with type 2 diabetes mellitus and 46 non-diabetic individuals of similar age and sex. The periodontal status was analyzed with the following indexes: oral hygiene index, calculus index, bleeding on probing index, periodontal pocket depth and attachment loss. Venous blood samples were obtained to analyze the systemic inflammation from the serum levels of inflammatory mediators such as ultrasensitive C-Reactive Protein (hsCRP), TNF-α and IL-6.
Results. There were no differences between the diabetic group and the control group with regard to plaque index, calculus and bleeding on probing. The mean depth of the periodontal pockets of the diabetic group was 2.53 ± 0.96 mm and 2.11 ± 0.59 mm in the control group, the depth of the periodontal pockets being higher in the diabetic group (p = 0.014). Similarly, the average attachment loss was also higher in the diabetic group (p = 0.028). A greater value was observed in both the index of bleeding on probing and the depth of the periodontal pockets in the poorly controlled (PC) group with respect to the control group.
The hsCRP levels were significantly higher in the group of patients with type 2 diabetes mellitus (p = 0.005). A correlation between hsCRP levels and periodontal status in diabetic patients was observed. The diabetic patients presented worse periodontal status than the controls, with a greater average depth of periodontal pockets and attachment loss in respect to the control group. The average depth of the periodontal pockets in diabetic patients with a poor metabolic control was greater respect to control group.
Discussion. In conclusion, diabetic patients presented a worse periodontal status than control patients, with a greater average depth of periodontal pockets and attachment loss, worsening the average depth of periodontal pockets when the metabolic control worsens. There is a tendency to increase the systemic levels of hsCRP due to an increase in the calculus and bleeding on probing indexes, indicating a tendency to increase inflammation when the periodontal status worsens.
References
1. Diagnosis and classification of diabetes mellitus. Diabetes Care. 2014;37 Suppl 1: S81-S90.
2. Negrato CA, Tarzia O. Buccal alterations in diabetes mellitus. Diabetol Metab Syndr. 2010; 2:3.
3. Soell M, Hassan M, Miliauskaite A, Haikel Y, Selimovic D. The oral cavity of elderly patients in diabetes. Diabetes Metab. 2007;33 Suppl 1: S10-S18.
Keywords:
Diabetes mellitus type 2,
Periodontal disease,
Cytokines,
Oral Medicine,
Oral Biology
Conference:
5th National and 1st International Symposium of Italian Society of Oral Pathology and Medicine., Ancona, Italy, 19 Oct - 20 Oct, 2018.
Presentation Type:
Poster Presentation
Topic:
Oral Diseases
Citation:
Silvestre-Rangil
J,
Gabrione
F,
Oberti
L,
Lucchese
A,
Carinci
F and
Lauritano
D
(2019). Periodontal disease and its relationship with ultrasensitive C-Reactive Protein (hsC-RP): a prospective, randomized, cross-sectional, case-control study in subjects with type 2 diabetes..
Front. Physiol.
Conference Abstract:
5th National and 1st International Symposium of Italian Society of Oral Pathology and Medicine..
doi: 10.3389/conf.fphys.2019.27.00001
Copyright:
The abstracts in this collection have not been subject to any Frontiers peer review or checks, and are not endorsed by Frontiers.
They are made available through the Frontiers publishing platform as a service to conference organizers and presenters.
The copyright in the individual abstracts is owned by the author of each abstract or his/her employer unless otherwise stated.
Each abstract, as well as the collection of abstracts, are published under a Creative Commons CC-BY 4.0 (attribution) licence (https://creativecommons.org/licenses/by/4.0/) and may thus be reproduced, translated, adapted and be the subject of derivative works provided the authors and Frontiers are attributed.
For Frontiers’ terms and conditions please see https://www.frontiersin.org/legal/terms-and-conditions.
Received:
11 Oct 2018;
Published Online:
09 Dec 2019.
*
Correspondence:
Dr. Javier Silvestre-Rangil, University of Valencia, Department of Stomatology, Valencia, Valencian Community, 46010, Spain, marcomascitti86@hotmail.it