Recent advances in the treatment of epilepsy

Khojasteh Malekmohammad, Mahmoud Rafieian-Kopaei, Antonella Riva

Frontiers Media SA

Epilepsy is one of the most common neurological chronic disorders characterized by unpredictable...

Science Pharmacology Analytical and Experimental Pharmacology

Keywords: Epilepsy,­Drug Development,­pharmacokinetics,­Pharmacodynamics,­Drug Discovery,­Pharmacological Targets

Clinical trials in drug metabolism and transport: 2022

Yurong Lai, Stanislav Yanev, Zhihao Liu

Frontiers Media SA

Science Pharmacology Drug Metabolism and Transport

Keywords: clinical trials,­drug-metabolizing enzymes,­drug transporters,­pharmacokinetics,­Pharmacodynamics

Drug metabolism and transport: The frontier of personalized medicine

Junmin Zhang, Rong Wang, Sofia Azeredo Pereira

Frontiers Media SA

Science Pharmacology Drug Metabolism and Transport

Keywords: drug metabolism,­Drug Transport,­pharmacokinetics,­drug-drug interactions,­Metabolic enzymes,­drug transporters,­external factors,­Gut Microbiota

Drug-drug interactions in pharmacology

Francesco Paolo Busardò, Simona Pichini, Oscar Garcia-Algar

Frontiers Media SA

Science Pharmacology Drug Metabolism and Transport

Keywords: Drug-interaction,­Medicine,­Pharmacotoxicology,­Cardiology,­oncology

Pharmacokinetic differences of drugs and their regulatory mechanisms under dual status including normal and diseased organism

Zipeng Gong, Ling Ye, Guo Ma, Kaustubh Kulkarni, Yan-Fang Xian

Frontiers Media SA

Science Pharmacology Drug Metabolism and Transport

Keywords: Dual status,­Pharmacokinetic differences,­drug metabolizing enzymes,­transporters,­Nuclear Receptors,­Gut Microbiota,­Pharmacokinetic-pharmacodynamic link model

Methods and Application in Drug Metabolism and Transport: 2021

Ren-ai Xu, Jiao Zheng, Sabina Passamonti

Frontiers Media SA

Science Pharmacology Drug Metabolism and Transport

Keywords: drug metabolism,­Pharmacology,­antitumor,­Blood deficiency syndrome,­Pharmacokinetic models

Organic Cation Transporter 1 (OCT1): Not Vital for Life, but of Substantial Biomedical Relevance

Jurgen Brockmoller, Mladen Vassilev Tzvetkov, Shuiying Hu

Frontiers Media SA

Around one third of all biologically relevant small molecules are organic cations. These include...

Science Pharmacology Drug Metabolism and Transport

Keywords: OCT1,­drug membrane transporter,­polymorphism,­pharmacokinetics,­structure and function

Pharmacokinetic Evaluation and Modeling of Clinically Significant Drug Metabolites

Constantin Mircioiu, Momir Mikov, Victor A. Voicu, Adrian Nicolescu, Valentina Anuta

Frontiers Media SA

Science Pharmacology Drug Metabolism and Transport

Keywords: IVIVC,­Metabolites,­biorelevant dissolution testing,­First pass metabolism,­pharmacokinetics