Head and Neck Squamous Cell Carcinoma: Navigating the Dawn of Personalized Medicine

Ye Guo, Luis Abel Quiñones, Fujun Han

Frontiers Media SA

Head and neck cancers rank 6th in newly diagnosed cases and 7th in newly reported cancer deaths...

Science Pharmacology Pharmacology of Anti-Cancer Drugs

Keywords: epidermal growth factor receptor,­Head and neck squamous cell carcinoma,­Immune checkpoint inhibitor,­biomarker

Immune Checkpoints Regulatory Mechanisms and Immunotherapy Strategies in Gastrointestinal Tumors

Simona Gurzu, Rongxin Zhang, Qing Xi

Frontiers Media SA

Gastrointestinal cancers, including esophageal, stomach, colon, liver, and pancreatic cancer,...

Health Oncology Pharmacology of Anti-Cancer Drugs

Keywords: immune checkpoints,­PD-L1,­Immunotherapy,­Gastrointestinal cancers

Chronic Myeloid Leukemia: From Targeted Therapy to Treatment-Free Remission

Michele Massimino, Simona Soverini, Manuela Mancini, Stefania Stella

Frontiers Media SA

Chronic Myeloid Leukemia (CML) is a hematopoietic stem cell disorder driven by the BCR-ABL1...

Science Pharmacology Pharmacology of Anti-Cancer Drugs

Keywords: TfR,­TKIs,­CML,­BCR-ABL,­Leukemic stem cells,­molecular response

Decoding the Epigenetic Landscape: Elucidating Cancer Pathology and Identifying Novel Therapeutic Targets

Han Yao, Dawei Chen, Yichao Hou

Frontiers Media SA

Epigenetic modifications encompass a range of mechanisms that alter gene expression without...

Science Pharmacology Pharmacology of Anti-Cancer Drugs

Keywords: epigenetic modifications,­metabolic reprogramming,­cancer therapeutic,­Targets Bioinformatics,­artificial intelligence

Pharmacotherapeutics for Bone and Soft Tissue Tumours

Hong Duan, Wei Xu, Wenli Zhang

Frontiers Media SA

Accounting for approximately 1% of all new cancers diagnosed globally, bone and soft tissue...

Science Pharmacology Pharmacology of Anti-Cancer Drugs

Keywords: Bone oncology,­Soft tissue tumour,­chemotherapy,­systemic therapy,­molecular targeting inhibitor,­individualized therapy,­Combined chemotherapy

Innovative Approaches to Overcome Resistance and Toxicities of Anti-Cancer Drugs

Awanish Mishra, Dayanidhi Raman, Valeria Consoli

Frontiers Media SA

Although diagnosis and treatment of various cancer types have made significant strides recently,...

Science Pharmacology Pharmacology of Anti-Cancer Drugs

Keywords: Cancer; Signaling pathway; apoptosis; angiogenesis; drug repurposing; toxicity; resistance; biomarkers; chemotherapy; targeted therapy; survival; mortality; adverse events; mechanism; interaction; miRNA;

The Biomarkers, Mechanism, and Therapeutic Strategies of Cancer Immunotherapy Resistance

Mou Peng, Xin Jin, Yunliang Gao, Xiaoxin Ren

Frontiers Media SA

Over the decades, cancer immunotherapy has been a burgeoning science in medicine and an established...

Science Pharmacology Pharmacology of Anti-Cancer Drugs

Keywords: biomarker,­Cancer,­Immunotherapy,­immune microenvironment,­Resistance mechanism

EGFR-TKIs for Lung Cancer Treatment: Development, Application, and Side Effects

Qinglin Shen, Shengxi Chen, Hexiao Tang

Frontiers Media SA

Lung cancer is the malignant tumor with the highest incidence and mortality rate in the world. With...

Health Oncology Pharmacology of Anti-Cancer Drugs

Keywords: EGFR-TKIs,­lung cancer,­side effects,­application

Drug Discovery in Cancer Research: Success Stories and Open Challenges

Tashinga E. Bapiro, Wagdy Mohamed Eldehna, Viviana di Giacomo

Frontiers Media SA

In recent years, cancer drug development has witnessed significant advancements driven by...

Science Pharmacology Pharmacology of Anti-Cancer Drugs

Keywords: Drug Discovery,­Cancer,­targeted therapies,­Immunotherapy,­precision medicine,­Drug Resistance,­tumor heterogeneity