Molecular Targets in Oncological and Hematological Disease Management: Innovations in Precision Medicine

Adrian Bogdan Tigu, Stefan Eugen Szedlacsek, Gregory Wiedman

Frontiers Media SA

Targeted therapies use specific therapeutic agents that specifically target a molecule that is...

Science Pharmacology Translational Pharmacology

Keywords: targeted therapy,­precision medicine,­Molecular diagnosis,­innovations,­Nanomedicine

Pharmacoinformatics: New developments and challenges in drug design

David Ramirez, Rafael Pelaez, Carlos F. Lagos, Jose L. Medina-Franco

Frontiers Media SA

Pharmacoinformatics combines bio- and chemoinformatics approaches as well as artificial...

Science Pharmacology Translational Pharmacology

Keywords: bioinformatics,­chemoinformatics,­drug design,­Multitarget drug design,­System Pharmacology Network Pharmacology,­machine learning,­artificial intelligence,­QSAR/QSRP modeling Ligand-based drug design,­structure-based drug design,­molecular docking,­molecular dynamics simulations,­Virtual Screening,­ADME/Tox prediction

Recent advances in the treatment of epilepsy

Khojasteh Malekmohammad, Mahmoud Rafieian-Kopaei, Antonella Riva

Frontiers Media SA

Epilepsy is one of the most common neurological chronic disorders characterized by unpredictable...

Science Pharmacology Analytical and Experimental Pharmacology

Keywords: Epilepsy,­Drug Development,­pharmacokinetics,­Pharmacodynamics,­Drug Discovery,­Pharmacological Targets

Innovative Pharmacometric Approaches to Inform Drug Development and Clinical Use

Victor Mangas Sanjuan, Zinnia P. Parra-Guillen, Maria Garcia-Cremades, Hugo Geerts

Frontiers Media SA

Pharmacometrics represents a strategy to optimize and rationalize decision-making process...

Science Pharmacology Translational Pharmacology

Keywords: pharmacometrics,­population analysis,­physiologically based pharmacokinetic modeling,­PBPK,­Quantitative Systems Pharmacology,­QSP,­Pharmacokinetic-pharmacodynamic model

Sepsis: Basic, Clinical and Therapeutic Approaches

Hong Zhou, Yan Kang, Lefu Lan, Daolin Tang

Frontiers Media SA

Science Pharmacology Experimental Pharmacology and Drug Discovery

Keywords: Sepsis,­Pathogenesis,­signal transduction pathway,­Treatment,­therapeutic strategies

Protection and healing in the digestive system and other tissues: Novel factors, mechanisms, and pharmaceutical targets

Predrag Sikiric, Thomas Brzozowski, Duan Chen, Ki Baik Hahm, Sven Seiwerth

Frontiers Media SA

Science Pharmacology Gastrointestinal and Hepatic Pharmacology

Keywords: gastrointestinal intergrity,­Ulcer healing,­Mucosal defense,­organ healing,­GI-tract

Model-informed drug development and evidence-based translational pharmacology

Yu-Wei Lin, S. Y. Amy Cheung, Songwen Tan, Weiguo Li, Chuanpin Chen, Amal Kaddoumi, Xiu-Li Guo

Frontiers Media SA

Science Pharmacology Translational Pharmacology

Keywords: pharmacometrics,­Drug Development,­Clinical observations,­Advanced analysis tools,­Cellular and molecular mechanics

Advance in Translational Research of Preterm Birth and Related Pregnancy

Nanbert Zhong, Thomas McElrath, Hao Ying

Frontiers Media SA

Science Pharmacology Obstetric and Pediatric Pharmacology

Keywords: Adverse outcome of pregnancy,­Pathological pregnancy,­biomarker,­Advanced technology,­Pathogenesis,­Therapeutic target,­Molecular pathway,­Placenta,­omics

Recent Advances in Radiation Medical Countermeasures

Ales Tichy, Diane Riccobono, Lynnette H. Cary, Christophe Badie

Frontiers Media SA

Science Pharmacology Translational Pharmacology

Keywords: radioprotection,­ionising radiation,­Acute Radiation Syndrome,­Radiocontamination