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8013 results for  (leptin OR ob).
Displaying 1 - 20 out of 8013 Search Results

Blockade of the leptin-sensitive pathway markedly reduces alcohol consumption in mice.

The neuropeptide leptin links adipose stores with hypothalamic centers and serves as an endocrine ... in two strains of spontaneously mutant mice that lack leptin (ob/ob) or the leptin receptor (db/db). ...

Emergence of leptin in infection and immunity: Scope and challenges in vaccines formulation

Deficiency of leptin (ob/ob) and/or desensitization of leptin signaling (db/db) and elevated expression of ... Suresh Kumar Kalangi, Dayakar Alti, Chandrasekaran Sambamurthy ...

Leptin modulates the T-cell immune response and reverses starvation-induced immunosuppression.

immunity of mice now known to be defective in leptin (ob/ob) or its receptor (db/db), has never been explained ... G M Lord, G Matarese, J K Howard, R J Baker, S R Bloom, R I Lechler ...

Brain stem is a direct target for leptin's action in the central nervous system.

gray of the brain stem of leptin-injected mice. These findings represent physiologically functional leptin Ob-Rb receptor in the brain stem as well ... Toru Hosoi, Toru Kawagishi, Yasunobu Okuma, Jun ...

Cerebrospinal fluid and plasma leptin measurements: covariability with dopamine and cortisol in fasting humans.

Leptin (OB protein) is an important signal in the regulation of energy balance. Leptin levels correlate with adiposity, but also decrease ... M M Hagan, P J Havel, R J Seeley, S C Woods, N N Ekhator, D G ...

Evidence that glucose metabolism regulates leptin secretion from cultured rat adipocytes.

glucose metabolism in the regulation of leptin secretion, we examined the effects of insulin and ... and sodium fluoride markedly decreased the leptin (ob) messenger RNA content of cultured adipocytes, but ...

Effects of tumor necrosis factor alpha on leptin secretion and gene expression: relationship to changes of glucose metabolism in isolated rat adipocytes.

to tumor necrosis factor-alpha (TNF-alpha) on leptin secretion from and leptin (OB) gene expression in isolated adipocytes. Because glucose ... E A Medina, K L Stanhope, T M Mizuno, C V Mobbs, F Gregoire ...

Evidence suggesting that galanin (GAL), melanin-concentrating hormone (MCH), neurotensin (NT), proopiomelanocortin (POMC) and neuropeptide Y (NPY) are targets of leptin signaling in the hypothalamus.

Leptin (OB protein) reduces food intake by acting at the hypothalamic level. The purpose of the ... Animals, Hypothalamus, Injections, Intraventricular, Leptin, male, Neuropeptides, Proteins, RNA ...

Synergistic induction of nitric oxide synthase type II: in vitro effect of leptin and interferon-gamma in human chondrocytes and ATDC5 chondrogenic cells.

To study, in vitro, the effect of leptin (OB), alone or in combination with interferon-gamma (IFNgamma ... Miguel Otero, Juan Jesús Gomez Reino, Oreste Gualillo ...

Testosterone substitution normalizes elevated serum leptin levels in hypogonadal men.

The ob gene product leptin (OB) is a feedback signal from the adipocyte to the hypothalamus and is ... T) substitution in hypogonadal men on serum OB levels. Hypogonadal men with T levels of 3.6 nmol/L ...

Localization of binding sites in the central nervous system for leptin (OB protein) in normal, obese (ob/ob), and diabetic (db/db) C57BL/6J mice.

Leptin (OB protein) fused to the FLAG epitope and a kinase recognition site was expressed in ... M. From our results, we hypothesize that the binding of leptin to its site may cause the release or ...

Leptin--the fat controller.

control of obesity, the recent discovery of leptin (OB) has made the obesity research interesting. OB, a product of ob gene ... Animals, female, Humans, Leptin, male, Mice, Mice, Knockout, Obesity ...

Leptin and OB-R: body weight regulation by a cytokine receptor.

and pathways governing mammalian body weight regulation. Leptin (OB), an ancestral member of the cytokine family ... D W White, L A Tartaglia ...

Sunjee Ob Ob

Sunjee Ob Ob ... Join the Frontiers Community. Frontiers People highlights some of the most notable researchers worldwide. ...

Cerulenin mimics effects of leptin on metabolic rate, food intake, and body weight independent of the melanocortin system, but unlike leptin, cerulenin fails to block neuroendocrine effects of fasting.

act through mechanisms similar to mechanisms engaged by leptin, ob/ob and Ay (agouti) mice, as well as fed and ... H Makimura, T M Mizuno, X J Yang, J Silverstein, J Beasley, C V Mobbs ...

Evidence for an interaction between leptin, T cell costimulatory antigens CD28, CTLA-4 and CD26 (dipeptidyl peptidase IV) in BCG-induced immune responses of leptin- and leptin receptor-deficient mice.

DPP IV, CD26) in the context of leptin or leptin receptor deficiency. C57BL/6 mice, Leptin-deficient mice (ob/ob mice, B6.V-Lep<ob>) and Leptin-receptor-deficient ...

Leptin requirement for conception, implantation, and gestation in the mouse.

body weight and sexual maturation (5 mg/kg, ip), leptin-treated ob/ob females were mated with either wild-type (+/+) or leptin-treated ob/ob males. The leptin treatment ... N M Malik, N D Carter, J F ...

In vitro lipolytic effect of leptin on mouse adipocytes: evidence for a possible autocrine/paracrine role of leptin.

These in vitro studies suggest an autocrine/paracrine action of leptin on white fat cells and envisages the involvement of the OB protein, not only in centrally mediated pathways, but ...

Altered sleep regulation in leptin-deficient mice.

study, we tested the hypothesis that leptin deficiency leads to impairments in sleep-wake regulation. Male ob/ob mice, a genetic model of leptin deficiency ... Aaron D Laposky, Jonathan Shelton, Joseph ...

Liver-specific disruption of PPARgamma in leptin-deficient mice improves fatty liver but aggravates diabetic phenotypes.

elucidate the function of PPARgamma in leptin-deficient mouse (ob/ob) liver, a PPARgamma liver-null mouse on an ob/ob background, ob/ob-PPARgamma ... Kimihiko Matsusue, Martin Haluzik, Gilles Lambert ...

Displaying 1 - 20 out of 8013 Search Results