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18 results for  Alan Ezekowitz.
Displaying 1 - 18 out of 18 Search Results

The mannose-binding lectin: an infection susceptibility gene.

R Alan Ezekowitz, Lei Shi, Iain Fraser, Kazue Takahashi ... Animals, Communicable Diseases, Genetic Predisposition to Disease, Humans, Mannose-Binding Lectin, Mice, Staphylococcal Infections ...

Arthritis critically dependent on innate immune system players.

K/BxN T cell receptor transgenic mice are a model of inflammatory arthritis, similar to ... V Michael Holers, Mark Walport, Craig Gerard, Alan Ezekowitz, Michael C Carroll, Michael Brenner, Ralph ...

Double-stranded RNA is internalized by scavenger receptor-mediated endocytosis in Drosophila S2 cells.

Double-stranded RNA (dsRNA) fragments are readily internalized and processed by Drosophila S2 cells ... Mataleena Parikka, Anni Kleino, Raija Sormunen, R Alan Ezekowitz, Christine Kocks, Mika Rämet ...

Preclinical characterization and first-in-human administration of a selective monoacylglycerol lipase inhibitor, ABX-1431

Background: Monoacylglycerol lipase (MGLL) is a serine hydrolase that breaks down ... Jason Clapper, Cheryl Grice, Gary O'Neill, Alan Ezekowitz, Archie Thurston, Els Geenens, Corinne Vandermeulen ...

Investigations on the involvement of the lectin pathway of complement activation in anaphylaxis.

Systemic anaphylaxis is the most severe form of immediate hypersensitivity ... Windbichler, Bernd Echtenacher, Kazue Takahashi, R Alan B Ezekowitz, Wilhelm J Schwaeble, Jens C Jenseniuis, Daniela N ...

The role of the mannose-binding lectin in innate immunity.

The innate immune system, which includes mannose-binding lectin (MBL), recognizes a broad range of molecular patterns on a broad range of infectious agents and is ... Kazue Takahashi, R Alan B Ezekowitz ...

Eater, a transmembrane protein mediating phagocytosis of bacterial pathogens in Drosophila.

Ju Hyun Cho, Nadine Nehme, Johanna Ulvila, Alan M Pearson, Marie Meister, Charles Strom, Stephanie L ... Stehle, Jules A Hoffmann, Jean-Marc Reichhart, Dominique Ferrandon, Mika Rämet, R Alan B Ezekowitz ...

Mannose-binding lectin-deficient mice display defective apoptotic cell clearance but no autoimmune phenotype.

Mannose-binding lectin (MBL) is a circulating serum protein that is sequestered to sites of inflammation and infection. MBL ... Lynda M Stuart, Kazue Takahashi, Lei Shi, John Savill, R Alan B Ezekowitz ...

Characterization of an equine mannose-binding lectin and its roles in disease.

The mannose-binding lectin (MBL), a pattern recognition serum protein, participates in the innate ... J Podolsky, Aaron Lasker, M Julia B F Flaminio, Lakshmi D Gowda, R Alan B Ezekowitz, Kazue Takahashi ...

The mannose-binding lectin: a prototypic pattern recognition molecule.

The innate immune system is comprised of a sophisticated network of recognition and effector molecules that act together to protect ... Kazue Takahashi, Wk Eddie Ip, Ian C Michelow, R Alan B Ezekowitz ...

Mannose-binding lectin-deficient mice are susceptible to infection with Staphylococcus aureus.

Gram-positive organisms like Staphylococcus aureus are a major cause of morbidity and mortality worldwide ... Jens Christian Jensenius, Faten Gad, Michael R Hamblin, Kedarnath N Sastry, R Alan B Ezekowitz ...

Mannose-binding lectin is a regulator of inflammation that accompanies myocardial ischemia and reperfusion injury.

The mannose-binding lectin (MBL), a circulating pattern recognition molecule, recognizes a wide range of ... Lei Shi, Marc N Busche, Russell P Rother, Scott D Solomon, R Alan B Ezekowitz, Gregory L Stahl ...

Lack of mannose-binding lectin-A enhances survival in a mouse model of acute septic peritonitis.

The mannose-binding lectin (MBL) (also known as the mannose-binding protein) is a serum protein that ... Motwani, Inga Laursen, Steffen Thiel, Jens Christain Jensenius, Michael Carroll, R Alan B Ezekowitz ...

Human peptidoglycan recognition protein S is an effector of neutrophil-mediated innate immunity.

Innate immune responses to bacteria require cooperative interactions between host recognition ... Iain P Fraser, Koichi Fukase, Shoichi Kusumoto, Yukari Fujimoto, Gregory L Stahl, R Alan B Ezekowitz ...

Response to Staphylococcus aureus requires CD36-mediated phagocytosis triggered by the COOH-terminal cytoplasmic domain.

Phagocyte recognition and clearance of bacteria play essential roles in the host response to ... M Silver, Kazue Takahashi, Anita A Tseng, Elizabeth J Hennessy, R Alan B Ezekowitz, Kathryn J Moore ...

Relative roles of complement factor 3 and mannose-binding lectin in host defense against infection.

Staphylococcus aureus is a major cause of severe nosocomial and community-acquired infections. Phagocytes and humoral molecules ... Kazue Takahashi, Lei Shi, Lakshmi D Gowda, R Alan B Ezekowitz ...

Deficiency of mannose-binding lectin greatly increases susceptibility to postburn infection with Pseudomonas aeruginosa.

Burn injury disrupts the mechanical and biological barrier that the skin presents against infection ... D Gowda, Michael R Hamblin, Steffen Thiel, Jens Chr Jensenius, R Alan B Ezekowitz, Kazue Takahashi ...

Mannose-binding lectin deficiency alters the development of fungal asthma: effects on airway response, inflammation, and cytokine profile.

Aspergillus fumigatus is a major fungal pathogen that may be fatal to immunocompromised individuals and causes ... Cory M Hogaboam, Kazue Takahashi, R Alan B Ezekowitz, Steven L Kunkel, Jane M Schuh ...

Displaying 1 - 18 out of 18 Search Results