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11 results for  Jan De Hoon.
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Jan De Hoon

Jan De Hoon ... Headache, Migraine Disorders, Motilin, Neurogenic Inflammation, biomarker, Conference report, humanized monoclonal antibody, NSAIDs, Migrating Motor Complex, TRPA1, activity-based protein ...

Calcitonin gene-related peptide: exploring its vasodilating mechanism of action in humans.

In vitro studies suggest that the vasodilator mechanism of action of calcitonin gene-related peptide (CGRP ... Jan N de Hoon, Peter Pickkers, Paul Smits, Harry A J Struijker-Boudier, Luc M A B Van Bortel ...

Intra- and interindividual variability of glucuronidation of paracetamol during repeated administration of propacetamol in neonates.

Major changes in drug clearance and metabolism are observed during infancy, in part based on ontogenic ... Karel Allegaert, Jan de Hoon, Rene Verbesselt, Christine Vanhole, Hugo Devlieger, Dick Tibboel ...

Intravenous paracetamol (propacetamol) pharmacokinetics in term and preterm neonates.

The aim of this study was to describe propacetamol pharmacokinetics in term and ... Karel Allegaert, Brian J Anderson, Gunnar Naulaers, Jan de Hoon, Rene Verbesselt, Anne Debeer, Hugo Devlieger, Dick ...

TRPA1 activation by cinnamaldehyde as target engagement biomarker: unraveling the involvement of secondary mediators

1. Buntinx L, Chang L, Amin A, Morlion B, de Hoon J. Development of an in vivo target-engagement biomarker for ... Linde Buntinx, Sergio Barroso, Joyce Vandendriessche, Lin Chang, Bart Morlion, Jan de Hoon ...

Nonselective cyclo-oxygenase inhibitors and glomerular filtration rate in preterm neonates.

The adverse effects of nonselective cyclo-oxygenase (COX) inhibitors on the immature kidney have ... Karel Allegaert, Christine Vanhole, Jan de Hoon, Jean Pierre Guignard, Dick Tibboel, Hugo Devlieger ...

EUFEMED London Conference 2017: Exploratory medicines development: innovation and risk management

The first formal conference of the EUropean Federation for Exploratory MEdicines Development (EUFEMED ... Yves Donazzolo, Ingrid Klingmann, Michael Hammond, Tim Hardman, Steffan Stringer, Jan de Hoon ...

The impact of ibuprofen on renal clearance in preterm infants is independent of the gestational age.

The aim of this investigation was to evaluate whether the relative change in renal clearance due to ... Veerle Cossey, Anne Debeer, Jean Paul Langhendries, Bart Van Overmeire, Jan de Hoon, Hugo Devlieger ...

Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of the CGRP Binding Monoclonal Antibody LY2951742 (Galcanezumab) in Healthy Volunteers

Background: Calcitonin gene-related peptide (CGRP) is pivotal in the pathophysiology of migraine headaches and ... Anne Vanhecken, Eyas Raddad, Joel Scherer, Thomas J Schuetz, David Grayzel, Jan De Hoon ...

Activation of PAC1 by maxadilan: a new human target engagement biomarker

Background: Maxadilan, isolated from the sand fly Lutzomyia longipalpis, is a potent vasodilator peptide activating the ... Linde Buntinx, Marleen Depre, Els Ampe, Anne Vanhecken, Jan de Hoon ...

Preclinical characterization and first-in-human administration of a selective monoacylglycerol lipase inhibitor, ABX-1431

Background: Monoacylglycerol lipase (MGLL) is a serine hydrolase that breaks down 2-arachidonoylglycerol ... Gary O'Neill, Alan Ezekowitz, Archie Thurston, Els Geenens, Corinne Vandermeulen, Jan de Hoon ...

Displaying 1 - 11 out of 11 Search Results