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15 results for  Matthijs Verhage.
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Matthijs Verhage

Matthijs Verhage ... Behavior, Learning, Memory, Fear conditioning, Individuality, animal model, Post-traumatic stress disorder, olfactory, behavioral phenotyping, Granule-cell mediated inhibition ...

The role of Munc18-1 in docking and exocytosis of peptide hormone vesicles in the anterior pituitary.

essential for synaptic vesicle secretion [Verhage, Maia, Plomp, Brussaard, Heeroma, Vermeer, Toonen ... Niki Korteweg, Ascanio S Maia, Brenda Thompson, Eric W Roubos, J Peter H Burbach, Matthijs Verhage ...

Vesicle trafficking: pleasure and pain from SM genes.

Most cells contain a variety of transport vesicles traveling to different destinations. Although many specific transport routes exist, the underlying molecular ... Ruud F G Toonen, Matthijs Verhage ...

Dissecting docking and tethering of secretory vesicles at the target membrane.

Secretory vesicles dock at their target in preparation for fusion. Using single-vesicle total ... de Wit, Attila Gulyas-Kovacs, Bas Konijnenburg, Jakob B Sørensen, Jurgen Klingauf, Matthijs Verhage ...

Identification of presynaptic gene clusters in synaptic signaling using functional data from genetic perturbation studies in Hippocampal autapses.

Synaptic gene function is typically studied by measuring the effect of a (genetic) perturbation of a ... L Cornelisse, Evgeni Tsivtsivadze, Marieke Meijer, Tjeerd Dijkstra, Tom Heskes, Matthijs Verhage ...

Probabilistic classification of presynaptic gene function using low-throughput generated functional data from genetic perturbation studies.

Classification of gene function based on functional data from genetic perturbation studies is generally ... Lennart Niels Cornelisse, Evgeni Tsivtsivadze, Tjeerd Dijkstra, Tom Heskes, Matthijs Verhage ...

Ca(2+)-induced recruitment of the secretory vesicle protein DOC2B to the target membrane.

Ca(2+)-dependent fusion of transport vesicles at their target can be enhanced by intracellular Ca2 ... J A Groffen, Elisabeth C Brian, Jeroen J Dudok, Joris Kampmeijer, Ruud F Toonen, Matthijs Verhage ...

Trophic support delays but does not prevent cell-intrinsic degeneration of neurons deficient for munc18-1.

from synaptic and large dense-cored vesicles [Verhage et al. (2000), Science, 287, 864-869; Voets et ... I van Aerde, Ruud F G Toonen, Robert A Hensbroek, Arjen Brussaard, Andrew Matus, Matthijs Verhage ...

Somatodendritic secretion in oxytocin neurons is upregulated during the female reproductive cycle.

During the female reproductive cycle, hypothalamic oxytocin (OT) neurons undergo sharp changes in ... W J Bosman, Rogier Min, Jan-Jurjen Koksma, Huibert D Mansvelder, Matthijs Verhage, Arjen B Brussaard ...

Munc18-1 stabilizes syntaxin 1, but is not essential for syntaxin 1 targeting and SNARE complex formation.

Munc18-1, a member of the Sec1/Munc18 (SM) protein family, is essential for synaptic vesicle exocytosis. Munc18-1 ... Ruud F G Toonen, Klaas Jan de Vries, Robbert Zalm, Thomas C Südhof, Matthijs Verhage ...

Vesicular trafficking of semaphorin 3A is activity-dependent and differs between axons and dendrites.

Secreted semaphorins act as guidance cues in the developing nervous system and may have additional functions in mature neurons. How ... Joris De Wit, Ruud F Toonen, Joost Verhaagen, Matthijs Verhage ...

Display of individuality in avoidance behavior and risk assessment of inbred mice

Factors determining individuality are still poorly understood. Rodents are excellent model organisms to ... N Manivannan, Ilan Golani, Sophie Van Der Sluis, August B Smit, Matthijs Verhage, Oliver Stiedl ...

Two distinct genes drive expression of seven tomosyn isoforms in the mammalian brain, sharing a conserved structure with a unique variable domain.

Tomosyn was previously identified as a syntaxin-binding protein that inhibits soluble NSF (n-ethylmaleimide-sensitive fusion ... Alexander J A Groffen, Linda Jacobsen, Désireé Schut, Matthijs Verhage ...

DOC2A and DOC2B are sensors for neuronal activity with unique calcium-dependent and kinetic properties.

Elevation of the intracellular calcium concentration ([Ca2+]i) to levels below 1 microm alters synaptic ... Alexander J A Groffen, Reut Friedrich, Elisabeth C Brian, Uri Ashery, Matthijs Verhage ...

Olfactory granule cell-specific silencing slows down odor discrimination time in mice

Introduction: The granule cells (GCs) of the olfactory bulb (OB) are axonless inhibitory interneurons, which form ... Bhavana Shrivastava, Ruud Toonen, Matthijs Verhage, Thomas Kuner ...

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