Neuroprotection by estrogenic compounds following inflammatory insult in the brain
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1
Pontificia Universidad Javeriana, Colombia
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2
Instituto Cajal, CSIC, Spain
The steady-state microglia play an important role in monitoring and protecting the nerve tissue ensuring proper functioning of the Central Nervous System. Microglia respond to an immune stimulus with the subsequent activation of cascades that trigger the secretion of pro-inflammatory cytokines (IL-1, TNF-α, IL-12). Neurodegenerative diseases and disorders such as spinal cord injury, stroke, and head trauma are directly related to chronic activation of microglia. Depending on the injury severity, the microglial response and activity may range from acute (beneficial) or chronic (detrimental), where this long-term activation are tightly associated to neurodegenerative processes. Several studies have reported that neuroactive steroids have protective effects and regulate the neuroinflammation associated to microglia. In cell therapy, microglia-induced inflammation may be modulated via the use of neurosteriods, due to their evidenced roles in the regulation of neuroinflammation. Estrogenic compounds, such as as SERM and STEARs, are currently under investigation. In this work, the regulatory mechanisms of inflammation of the microglia are discussed, including the reduction of inflammatory processes in the brain by treatment with neurosteroids.
Keywords:
Neurosteroids,
Microglia,
Inflammation,
Brain Injury,
Neuroprotection
Conference:
Latin-American School on glial cells in the diseased brain (IBRO), Bogotá, Colombia, 13 Jul - 17 Jul, 2015.
Presentation Type:
Poster Presentation
Topic:
Neural excitability, synaptic transmission, glia: Cellular and molecular mechanisms
Citation:
Lanussa
OH,
Ávila-Rodriguez
M,
Gonzalez
J,
Garcia-Segura
LM and
Barreto
G
(2015). Neuroprotection by estrogenic compounds following inflammatory insult in the brain
.
Conference Abstract:
Latin-American School on glial cells in the diseased brain (IBRO).
doi: 10.3389/conf.fncel.2015.35.00031
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Received:
22 Feb 2015;
Published Online:
11 Jun 2015.
*
Correspondence:
Prof. George E. Barreto, Pontificia Universidad Javeriana, Bogotá, Colombia, gesbarreto@gmail.com