TY - JOUR AU - Koussih, Latifa AU - Atoui, Samira AU - Tliba, Omar AU - Gounni, Abdelilah S. PY - 2021 M3 - Review TI - New Insights on the Role of pentraxin-3 in Allergic Asthma JO - Frontiers in Allergy UR - https://www.frontiersin.org/articles/10.3389/falgy.2021.678023 VL - 2 SN - 2673-6101 N2 - Pentraxins are soluble pattern recognition receptors that play a major role in regulating innate immune responses. Through their interaction with complement components, Fcγ receptors, and different microbial moieties, Pentraxins cause an amplification of the inflammatory response. Pentraxin-3 is of particular interest since it was identified as a biomarker for several immune-pathological diseases. In allergic asthma, pentraxin-3 is produced by immune and structural cells and is up-regulated by pro-asthmatic cytokines such as TNFα and IL-1β. Strikingly, some recent experimental evidence demonstrated a protective role of pentraxin-3 in chronic airway inflammatory diseases such as allergic asthma. Indeed, reduced pentraxin-3 levels have been associated with neutrophilic inflammation, Th17 immune response, insensitivity to standard therapeutics and a severe form of the disease. In this review, we will summarize the current knowledge of the role of pentraxin-3 in innate immune response and discuss the protective role of pentraxin-3 in allergic asthma. ER -