AUTHOR=Tripathi Lakshmi , Zhang Yan , Lin Zhanglin TITLE=Bacterial Sigma Factors as Targets for Engineered or Synthetic Transcriptional Control JOURNAL=Frontiers in Bioengineering and Biotechnology VOLUME=2 YEAR=2014 URL=https://www.frontiersin.org/journals/bioengineering-and-biotechnology/articles/10.3389/fbioe.2014.00033 DOI=10.3389/fbioe.2014.00033 ISSN=2296-4185 ABSTRACT=

Sigma (σ) factors are the predominant constituents of transcription regulation in bacteria. σ Factors recruit the core RNA polymerase to recognize promoters with specific DNA sequences. Recently, engineering of transcriptional regulators has become a significant tool for strain engineering. The present review summarizes the recent advances in σ factor based engineering or synthetic design. The manipulation of σ factors presents insights into the bacterial stress tolerance and metabolite productivity. We envision more synthetic design based on σ factors that can be used to tune the regulatory network of bacteria.